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Objective: To determine if a low admission Karnofsky Performance Scale (KPS) score is indicative of a higher likelihood of death within three months of discharge from inpatient rehabilitation with an active cancer diagnosis.
Design: A retrospective, observational design was employed to analyze electronic medical records of 385 patients with a primary or concurrent diagnosis of cancer admitted from a multi-center, acute inpatient rehabilitation hospital system between January 1, 2020, and December 31, 2020.
Results: Of the 385 patients, a total of 77 patients (20%) had an observed death within 3 months. Out of the sample of patients with an observed death within a 15-month window (n = 157), 49% died within 3 months of discharge from the IRF. Patients with a KPS score of 40 or less had a significantly higher risk of mortality within three months of discharge (Hazard ratio = 1.49, 95% CI 1.09-2.04, p = 0.013). For those surviving less than three months, average survival was 32 days. Improvements in KPS score during the inpatient stay were linked to better survival outcomes.
Conclusion: These findings provide insight into the prognosis of patients with cancer in inpatient rehabilitation, emphasizing the importance of functional assessment in predicting mortality within three months of discharge.
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http://dx.doi.org/10.1097/PHM.0000000000002754 | DOI Listing |
Pediatr Nephrol
September 2025
Division of Nephrology, Department of Pediatrics, All India Institute of Medical Sciences, Ansari Nagar, New Delhi, 110029, India.
Background: Kidney involvement in pediatric sarcoidosis is rare and often underrecognized, leading to diagnostic delays and treatment challenges. We report six patients with renal sarcoidosis to highlight their diverse presentations and outcomes and challenges in management.
Methods: Medical records of patients diagnosed with renal sarcoidosis during 2020-24 were reviewed.
Odontology
September 2025
Department of Periodontics, Saveetha Dental College and Hospital, Saveetha Institute of Medical and Technical Sciences, Saveetha University, Chennai, Tamil Nadu, India.
Orthodontic-induced gingival enlargement (OIGE) affects approximately 15-30% of patients undergoing orthodontic treatment and remains largely unpredictable, often relying on subjective clinical assessments made after irreversible tissue changes have occurred. S100A4 is a well-characterized marker of activated fibroblasts involved in pathological tissue remodeling. This was a cross-sectional precision biomarker study that analyzed gingival tissue samples from three groups: healthy controls (n = 60), orthodontic patients without gingival enlargement (n = 31), and patients with clinically diagnosed OIGE (n = 61).
View Article and Find Full Text PDFEye (Lond)
September 2025
Kim's Eye Hospital, Konyang University College of Medicine, Seoul, South Korea.
Objective: To compare the effectiveness of intravitreal faricimab and aflibercept injections in patients with polypoidal choroidal vasculopathy (PCV).
Methods: This retrospective study analysed 111 treatment-naïve eyes (111 patients) with PCV who received intravitreal injections of either faricimab (30 eyes) or aflibercept (81 eyes). All patients were treated with three initial monthly loading injections.
Eur J Orthop Surg Traumatol
September 2025
University of Leeds, Leeds, United Kingdom.
Introduction: This study aimed to evaluate the health perception of quality of life and function in patients with segmental bone defects (SBD) of the femur or tibia treated with the Induced Membrane Technique (IMT) and achieved bone healing and infection control.
Methods: This cross-sectional cohort study was conducted at a single referral center. Patients with infected SBD of the femur or tibia treated with IMT were included if they had at least 12 months of bone healing and no evidence of infection.
Eur J Clin Pharmacol
September 2025
Department of Clinical Pharmacy, Faculty of Pharmacy, Tanta University, Tanta, Egypt.
Objective: This research aimed at evaluating the effectiveness and safety of nitazoxanide and escitalopram as adjuvant therapies in patients with rheumatoid arthritis (RA).
Methods: In this randomized controlled parallel study, 90 patients with active RA were randomized into three groups; group 1 (control group; n = 30) which received traditional therapy, group 2 (Nitazoxanide group; n = 30) which received traditional therapy plus 1 gm/day oral nitazoxanide, and group 3 (Escitalopram group; n = 30) which received traditional therapy plus 10 mg/day oral escitalopram for three months. At baseline and 3 months after treatment, clinical and functional assessments were done through the 28-joint count disease activity score using C-reactive protein (DAS28-CRP), the health assessment questionnaire-disability index (HAQ-DI), and the patient's global assessment (PGA).