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Introduction: A 22-year-old male with no cardiovascular history presented with frequent symptomatic ventricular premature contractions (VPCs) with multiple QRS morphologies despite bisoprolol treatment.
Results: The coupling intervals progressively increased from VPC1 to VPC3, and VPC2 was the most frequent. The earliest activation site was identified at the left-right coronary cusp junction. Single ventricular extrastimuli with variable coupling intervals from this site successfully reproduced QRS morphologies identical to VPC1-3.
Conclusion: This case illustrated how a single focus VPC could exhibit multiform morphology due to varying fusion with intrinsic conduction and the importance of coupling interval-matched extrastimuli in identifying the origin.
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http://dx.doi.org/10.1111/jce.16684 | DOI Listing |
Cochrane Database Syst Rev
September 2025
Institute for Evidence in Medicine, Medical Center - University of Freiburg / Medical Faculty - University of Freiburg, Freiburg, Germany.
Rationale: Cervical cancer is the fourth most common cancer affecting women worldwide, caused by persistent infection with oncogenic human papillomavirus (HPV) types. While HPV infections usually resolve spontaneously, persistent infections with high-risk HPV types can progress to premalignant glandular or - mostly - squamous intraepithelial lesions, usually classified in cervical intraepithelial neoplasia (CIN). Women with CIN 2 and CIN 3 (i.
View Article and Find Full Text PDFAustralas J Ageing
September 2025
School of Nursing, Hungkuang University, Taichung, Taiwan.
Objective: Although existing evidence suggests a potential link between dementia and adverse outcomes in patients with COVID-19, a definitive relationship is uncertain. This study aimed to evaluate the impact of dementia on in-hospital outcomes of patients in the presence of COVID-19.
Methods: The US Nationwide Inpatient Sample (NIS) was searched for patients 65 years or older hospitalised for COVID-19 in 2020.
Heart Rhythm O2
August 2025
Department of Cardiovascular Medicine, The Cleveland Clinic, Cleveland, Ohio.
Background: Atrioventricular (AV) conduction time is rate-dependent. As the atrial coupling interval (A1A2) shortens, AV conduction time (A2H2) prolongs. Thus, the AV conduction curve, plotted using A1A2 vs A2H2, is usually "smooth" and "monotonic".
View Article and Find Full Text PDFJ Forensic Sci
September 2025
Laboratório de Ecologia Comportamental, Universidade Estadual de Mato Grosso do Sul (UEMS), Dourados, Mato Grosso do Sul, Brazil.
Blowflies are important to estimate the postmortem interval (PMI), since they are the first to interact with the carcass. However, depending on the decomposition stage, only pupae can be found. A method that has currently been suggested is the use of cuticular hydrocarbons (CHCs) in forensically important fly species to aid in estimating PMI; however, studies from the pupal stage are rare.
View Article and Find Full Text PDFMov Disord
September 2025
Department of Functional Neurosurgery, Affiliated Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Phase-amplitude coupling (PAC) in the beta-gamma range has emerged as a promising electrophysiological biomarker of Parkinson's disease (PD).
Objective: This study aims to investigate how levodopa and locomotion modulate cortical (central electroencephalogram [cEEG]) and corticomuscular (cEEG-gEMG [gastrocnemius electromyography]) beta-gamma PAC in patients with PD.
Methods: Thirty patients with PD underwent simultaneous cEEG and gEMG recordings during sitting, standing, and free walking in both off and on dopaminergic states.