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Managing perianal fistulae involves balancing the risks of incontinence and recurrence, with existing classification systems offering limited guidance for surgical decision-making. Garg's classification provides a detailed assessment of fistula anatomy, aiding the choice between fistulotomy and sphincter-sparing procedures. This study evaluates its predictive accuracy.
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http://dx.doi.org/10.1177/00494755251331323 | DOI Listing |
Cureus
July 2025
General Medicine, Maulana Azad Medical College, New Delhi, IND.
Systemic lupus erythematosus (SLE) is a heterogeneous autoimmune disease with a broad range of clinical manifestations. While musculoskeletal involvement is common in SLE, myositis as the initial and isolated presentation is rare and can lead to diagnostic delays. We report the case of a 19-year-old female who presented with progressive, symmetrical proximal muscle weakness over several weeks, without accompanying joint, cutaneous, or systemic symptoms.
View Article and Find Full Text PDFOphthalmology
August 2025
McMaster University, Department of Surgery, Division of Ophthalmology, 2757 King Street East, Hamilton, Ontario, Canada; McMaster University, Department of Health Research Methods, Evidence and Impact, 1280 Main Street West, Hamilton, Ontario, Canada.
Purpose: Determine effect estimates and certainty of evidence for the associations between baseline optical coherence tomography (OCT) biomarkers and (1) patients' visual acuity (VA) and (2) changes in VA from baseline to 6, 12, and 24 months after initiation of anti-vascular endothelial growth factor, steroid, or laser treatment for diabetic macular edema.
Clinical Relevance: Understanding the prognostic value conferred by biomarkers can help predict disease activity and inform treatment decisions.
Methods: This review was registered in PROSPERO (CRD42023487798).
J Med Virol
July 2025
Indian Council of Medical Research-National Institute of Virology [ICMR-NIV], Pune, Maharashtra, India.
Chandipura virus, a Vesiculovirus, was first identified in India during an outbreak investigation of acute febrile illness in 1965. The virus first gained global attention after being implicated as the causative agent of an outbreak of acute viral encephalitis characterized by rapid clinical deterioration and death, in 2003. Since then, the virus has caused multiple outbreaks in central and western Indian states.
View Article and Find Full Text PDFIndian J Radiol Imaging
July 2025
Department of Radiodiagnosis and Interventional Radiology, All India Institute of Medical Sciences, New Delhi, India.
The aim of this study was to explore an innovative approach for developing deep learning (DL) algorithm for renal cell carcinoma (RCC) detection and subtyping on computed tomography (CT): clear cell RCC (ccRCC) versus non-ccRCC using two-dimensional (2D) neural network architecture and feature consistency modules. This retrospective study included baseline CT scans from 196 histopathologically proven RCC patients: 143 ccRCCs and 53 non-ccRCCs. Manual tumor annotations were performed on axial slices of corticomedullary phase images, serving as ground truth.
View Article and Find Full Text PDFComput Biol Med
August 2025
Department of Psychiatry, Central Institute of Psychiatry, Kanke, Ranchi, India.
FMRI, a non-invasive neuroimaging technique, can detect emotional brain activation patterns. It allows researchers to observe functional changes in the brain, making it a valuable tool for emotion recognition. For improved emotion recognition systems, it becomes crucial to understand the neural mechanisms behind emotional processing in the brain.
View Article and Find Full Text PDF