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Structural biology is crucial in understanding disease mechanisms and in driving drug and vaccine development—applications that are particularly relevant to Africa’s challenges—yet Africa faces significant barriers to advancing structural biology. Here, the authors outline a recent capacity building workshop run by BioStruct-Africa, focused on training of artificial intelligence tools such as AlphaFold, designed to foster a highly skilled community of structural biologists in Africa.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12009398 | PMC |
http://dx.doi.org/10.1038/s42004-025-01519-w | DOI Listing |
Transl Behav Med
January 2025
Ingram School of Nursing, Faculty of Medicine and Health Sciences, McGill University, Montréal, Canada.
Background: Theories, models, and frameworks (TMFs) are central to the development and evaluation of implementation strategies supporting evidence-based practice (EBP). However, evidence on how and to what extent TMFs are used in implementation trials remains limited.
Purpose: This study aimed to examine the nature and extent of TMF use in implementation trials, identify which TMFs are most frequently employed, and explore temporal trends in their use.
Drugs Aging
September 2025
Dalla Lana School of Public Health, University of Toronto, V1 06, 2075 Bayview Avenue, Toronto, ON, M4N 3M5, Canada.
Background And Objectives: Older adults living with dementia are a heterogeneous group, which can make studying optimal medication management challenging. Unsupervised machine learning is a group of computing methods that rely on unlabeled data-that is, where the algorithm itself is discovering patterns without the need for researchers to label the data with a known outcome. These methods may help us to better understand complex prescribing patterns in this population.
View Article and Find Full Text PDFConserv Biol
September 2025
Alfred Toepfer Academy for Nature Conservation, Schneverdingen, Germany.
The importance of social science to address the human dimensions of natural resource management is increasingly recognized in the conservation field, yet the application of associated concepts, theories, methods, and data remains underrepresented in parts of Europe. Common barriers and gaps, persistent over decades, including institutional constraints, work environment, different cultures and languages between natural and social science disciplines, lack of qualified personnel, and an accessible professional community, are often cited as underlying and driving factors. To better understand, contextualize, and inform solutions for wider use of social science, we analyzed interactions with conservation researchers and practitioners across a series of organized events from 2018 to 2023 (e.
View Article and Find Full Text PDFGlob Chang Biol
September 2025
Institute for Biodiversity and Ecosystem Dynamics (IBED), University of Amsterdam, Amsterdam, the Netherlands.
Droughts are increasing with climate change, affecting the functioning of terrestrial ecosystems and limiting their capacity to mitigate rising atmospheric CO levels. However, there is still large uncertainty on the long-term impacts of drought on ecosystem carbon (C) cycling, and how this determines the effect of subsequent droughts. Here, we aimed to quantify how drought legacy affects the response of a heathland ecosystem to a subsequent drought for two life stages of Calluna vulgaris resulting from different mowing regimes.
View Article and Find Full Text PDFFront Health Serv
August 2025
Department of Medical Laboratory Sciences, University of Nigeria, Enugu, Nigeria.
Introduction: In sub-Saharan Africa, the burden of sickle cell disease remains high. With annual sickle cell births of about 150,000, Nigeria is reported to have the highest prevalence of the disease globally. This study aimed to explore the views and perspectives of healthcare professionals regarding access to healthcare services for sickle cell disease.
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