Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The National Cancer Database (NCDB) is widely used in US cancer outcomes research, but its reliance on Commission on Cancer-approved hospitals can underrepresent certain populations, skew data, and limit generalizability of findings. Current literature is representative up through 2014. We sought to adjust NCDB cancer cases to better reflect total US cancer population in a useful way for cancer outcomes research.
Methods: Incident cancer cases in the NCDB from 2016-2020 were compared with the US Cancer Statistics (USCS) database, which contains nearly 100% of new cancer cases. NCDB case coverage was defined as percentage of cases the NCDB represents of USCS cases. Coverage was determined for the entire cohort (age 20+ years), and sub-analyses were performed for age, sex, race/ethnicity, residence location, and cancer sites.
Results: From 2016-2020, 6,515,675 cancer cases were diagnosed in the NCDB and 9,311,593 in the USCS, yielding 70% NCDB case coverage over 5 years, which increased from 68 to 73%. The lowest case coverage was among men, 85+-year-olds, American Indian/Alaskan Native people, and Hispanic/Latino individuals (65%, 59%, 42%, and 55%). The Mountain region was the least represented (49%) as was nonmetropolitan residence (64%). Similar underrepresentation was seen among top cancers. Missingness of data was also captured.
Conclusions: Though NCDB's representation of US cancer cases is improving, gaps remain, including age, sex, race/ethnicity, and residence location, further exacerbated by missing variables. We provide investigators using the NCDB with a way to represent cancer case data to better tailor research questions and frame outcomes.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1245/s10434-025-17285-x | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Significant pain reduction in refractory post-mastectomy pain syndrome with closed-loop spinal cord stimulation: illustrative cases.
J Neurosurg Case Lessons
September 2025
Department of Anesthesiology, University of Arkansas for Medical Sciences, Little Rock, Arkansas.
Background: Breast cancer is one of the most common malignancies worldwide and is often treated with surgery. Post-mastectomy pain syndrome (PMPS) can have disabling consequences. The incidence of PMPS ranges from 20% to 68%.
View Article and Find Full Text PDFBackground: Oesophageal squamous cell carcinoma is the predominant histopathological subtype of oesophageal cancer across the world, representing as many as 90% of all cases; however, within Western cohorts, it is a low-prevalence disease, and, as such, appropriately powered trials to establish a standard treatment paradigm in this population remain challenging. The aim of this study was to assess current practices and compare outcomes for patients with locally advanced oesophageal squamous cell carcinoma across the UK and Ireland.
Methods: This was a retrospective multicentre cohort study of patients managed with curative intent for squamous cell carcinoma of the middle or distal oesophagus in 23 hospitals across the UK and Ireland.
A prospective, multicenter study of invasive fungal disease caused by molds in children and adults in Chile.
PLoS One
September 2025
Chilean Invasive Mycosis Network, Santiago, Chile.
Background: Invasive mold diseases (IMDs) are a severe complication of immunocompromised subjects and an emerging problem among severely ill, apparently immunocompetent patients. The aim of this study was to describe the epidemiological and clinical features of IMDs in Chile.
Methods: Prospective study of IMD cases in children and adults from 11 reference hospitals in Chile from May 2019 to May 2021.
Drug-induced vitiligo: a real-world pharmacovigilance analysis of the FAERS database.
PLoS One
September 2025
Geriatric Medicine Center, Department of Nursing, Zhejiang Provincial People's Hospital (Affiliated People's Hospital), Hangzhou Medical College, Hangzhou, Zhejiang, China.
Background: In recent years, with the expanding use of novel therapeutics such as immune checkpoint inhibitors and monoclonal antibodies, reports of drug-induced vitiligo have been increasing. This study aimed to identify drugs associated with vitiligo using the FDA Adverse Event Reporting System (FAERS).
Methods: A retrospective disproportionality analysis was performed on FAERS reports from the first quarter of 2004 to the fourth quarter of 2024.
Negative Pressure Wound Therapy: An Adjunct in Reconstructing Large Periocular Defects From Necrotizing Fasciitis.
J Craniofac Surg
September 2025
Department of Surgery, Cumming School of Medicine, University of Calgary, Calgary, Alberta.
Purpose: To demonstrate the use of negative pressure wound therapy (NPWT) and other reconstructive techniques in the reconstruction of large tissue defects resulting from periocular necrotizing fasciitis (NF).
Methods: Description of technique with 3 illustrative cases and accompanying photographic montage.
Results: Technique: Debridement successfully spared post-septal tissues and the lid margin in all cases.