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http://dx.doi.org/10.1016/j.lanmic.2025.101124 | DOI Listing |
BMC Public Health
September 2025
Uganda Public Health Fellowship Program, Uganda National Institute of Public Health, Kampala, Uganda.
Background: Cholera is endemic in Uganda with periodic outbreaks occurring annually. On July 24, 2023, Uganda's Ministry of Health confirmed a cholera outbreak in Sigulu Island, Namayingo District. We investigated to determine its magnitude, identify possible exposures, and recommend evidence-based control interventions.
View Article and Find Full Text PDFVaccines (Basel)
August 2025
Escola Superior de Saúde, Instituto Politécnico do Porto, Rua Dr. António Bernardino de Almeida, 4200-072 Porto, Portugal.
Background/objectives: Influenza represents a significant burden on global public health, and vaccination is the most effective strategy to reduce it. The large investment in vaccination programs and the need for adjustments in vaccine serotypes are important reasons for evaluating the influenza vaccine's efficacy every year. Establishing a relationship between immunogenicity data and efficacy is also crucial for predicting the efficacy of a vaccine during its development.
View Article and Find Full Text PDFVaccines (Basel)
August 2025
National Institutes for Food and Drug Control, NHC Key Laboratory of Research on Quality and Standardization of Biotech Products, State Key Laboratory of Drug Regulatory Science, NMPA Key Laboratory for Quality Research and Evaluation of Biological Products, Beijing 102629, China.
Background/objectives: The immunogenicity of Streptococcus pneumoniae vaccines is commonly evaluated by assessing the fold increase or proportions exceeding 0.35 μg/mL in serotype-specific IgG antibody levels post-vaccination. Establishing baseline antibody levels in unvaccinated populations is therefore essential for defining serological thresholds and understanding naturally acquired immunity.
View Article and Find Full Text PDFViruses
August 2025
School of Public Health (Shenzhen), Sun Yat-sen University, Guangzhou 510275, China.
As dengue is an increasing global health threat, a better understanding of the global circulation dynamics and its determinants would be helpful for precise prevention and control of dengue. The dynamics of global circulation of the four dengue virus serotypes were explored utilizing genetic sequences through a network-based method. Four new circulation indicators, including local intensity, betweenness centrality, tip frequency, and persistence time, were defined.
View Article and Find Full Text PDFVaccines (Basel)
August 2025
Shaanxi Provincial Center for Disease Control and Prevention, Xi'an 710054, China.
Objectives: This randomized, double-blind, active-controlled non-inferiority phase 4 clinical trial was conducted to evaluate the immunogenicity and safety of a 23-valent pneumococcal polysaccharide vaccine (PPSV23) compared to an active comparator vaccine.
Methods: Pneumococcal vaccine-naïve participants aged ≥2 years were randomly assigned in a 2:1 ratio to receive a single dose of either the investigational vaccine ( = 1199) or the comparator vaccine ( = 600). Immunogenicity was evaluated at baseline and 30 days post-vaccination by measuring serotype-specific IgG antibodies against all 23 pneumococcal serotypes using enzyme-linked immunosorbent assay.