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Background: Prolonged sedentary behavior in workplace settings is associated with increased health risks, including chronic diseases and reduced productivity. While various mobile health (mHealth) interventions exist, most focus on single behaviors such as physical activity (PA) or sedentary time, with limited solutions integrating diet, PA, and sedentary behavior for sedentary employees.
Objective: This study aimed to develop Simple Health, an evidence- and theory-based mHealth web app designed to promote healthy eating, increase PA, and reduce sedentary time among sedentary employees. The study also evaluated the app's usability.
Methods: The study followed a two-phase approach. In Phase 1, Simple Health was developed by a multidisciplinary team using social cognitive theory and the ecological model as theoretical foundations. Behavior change techniques such as goal-setting, self-monitoring, and personalized feedback were incorporated. In Phase 2, usability testing was conducted with eight sedentary employees. Participants used Simple Health for five days and completed the mHealth app usability questionnaire (MAUQ) to assess ease of use, interface satisfaction, and perceived usefulness. Open-ended feedback was also collected to identify areas for improvement.
Results: Most participants (87.5%) found Simple Health easy to use, with usability scores indicating favorable responses across ease of use (mean: 2.20/7), interface satisfaction (mean: 1.91/7), and usefulness (mean: 1.98/7). Participants valued the simplicity of behavior logging and the actionability of personalized advice. Suggestions for improvement included increasing goal-setting flexibility and refining navigation to enhance user experience.
Conclusions: The development and usability evaluation of Simple Health demonstrate its potential as a workplace mHealth intervention that integrates PA promotion, sedentary behavior reduction, and dietary tracking. While usability feedback was generally positive, refinements such as improved navigation and enhanced goal-setting flexibility could further optimize engagement. Future iterations should explore automatic syncing with wearable devices and expanded implementation in workplace wellness programs to assess long-term adoption and effectiveness.
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http://dx.doi.org/10.1186/s12889-025-22401-3 | DOI Listing |
Int J Soc Psychiatry
September 2025
Department of Community Medicine, All India Institute of Medical Sciences, Nagpur, MH, India.
Introduction: Night Eating Syndrome (NES) is a distinct psychopathological entity variously considered as a mental health disorder, eating disorder or circadian rhythm disorder. Medical students are faced with hectic schedules, sleep interruptions and high-stakes exams as they become healthcare providers. Such social factors coupled with poor dietary practices may impact their mental health and biological clocks, leading to NES amongst this population.
View Article and Find Full Text PDFMol Ther Methods Clin Dev
June 2025
Eisai Co., Ltd., Tsukuba Research Laboratories, 5-1-3, Tokodai, Tsukuba, Ibaraki 300-2635, Japan.
Liver-humanized chimeric mice (PXB-mice) are widely utilized for predicting human pharmacokinetics (PK) and as human disease models. However, residual metabolic activity of mouse hepatocytes in chimeric mice can interfere with accurate human PK estimation. Lipid nanoparticle (LNP)-formulated small interfering RNA (siRNA) treatment makes it possible to eliminate the shortcomings of chimeras and create new models.
View Article and Find Full Text PDFAlzheimers Dement (Amst)
September 2025
Introduction: Simple screening tools are critical for assessing Alzheimer's disease (AD)-related pre-dementia changes. This study investigated longitudinal scores from the Quick Dementia Rating System (QDRS), a brief study partner-reported measure, in relation to baseline levels of the AD biomarker plasma pTau217 in individuals unimpaired at baseline.
Methods: Data from the Wisconsin Registry for Alzheimer's Prevention (N = 639) were used to examine whether baseline plasma pTau217 (ALZpath assay on Quanterix platform) modified QDRS or Preclinical Alzheimer's Cognitive Composite (PACC3) trajectories (mixed-effects models; time = age).
Comput Biol Med
September 2025
Department of Biomedical Engineering, Linköping University, Linköping, Sweden; Center for Medical Image Science and Visualization (CMIV), Linköping University, Linköping, Sweden; School of Medical Sciences and Inflammatory Response and Infection Susceptibility Centre (iRiSC), Faculty of Medicine
Functional magnetic resonance imaging (fMRI) is a pivotal tool for mapping neuronal activity in the brain. Traditionally, the observed hemodynamic changes are assumed to reflect the activity of the most common neuronal type: excitatory neurons. In contrast, recent experiments, using optogenetic techniques, suggest that the fMRI-signal could reflect the activity of inhibitory interneurons.
View Article and Find Full Text PDFEncephale
September 2025
Département de psychiatrie de l'adolescent et du jeune adulte, institut mutualiste Montsouris, 42, boulevard Jourdan, Paris, France; UVSQ, Inserm U1178, PsyDev, CESP université Paris-Saclay, Villejuif, France; Université Paris-Cité, Paris, France.
The body of knowledge on trauma is rapidly expanding. Since 2022, the WHO has been calling for the history of adversity to be systematically taken into account when assessing the state of health of all individuals. But at this stage, our understanding of the precise mechanisms of complex trauma remains incomplete.
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