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Article Abstract
Two azaphilones designated as acetosellins A and B (1-2) and one new coumarin (3), along with eight other known compounds (4-11), were isolated from an endophyte Talaromyces pinophilus WRH-1 of Perilla frutescens (L.) Britt. Their structures were elucidated through detailed interpretation of UV, NMR, and HR-ESI-MS data. The absolute configurations of C-8 in compounds 1 and 2 were determined by spectroscopic analysis and ECD calculations, while C-3 configurations were established through computational C NMR and DP4+ analyses. The in vitro cytotoxic activities of 1 and 2 against H23 cell lines were measured using MTT assay, with IC values of 14.10 and 14.65 μM, respectively. Furthermore, compound 2 demonstrated medium inhibitory effects against Staphylococcus aureus and Bacillus subtilis, with MIC value of 32 μg/mL. Additionally, compounds 1 and 2 were found to be osteogenic in the prednisolone induced osteoporotic zebrafish at 4 μM and 2 μM, respectively.
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| http://dx.doi.org/10.1016/j.fitote.2025.106545 | DOI Listing |
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