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This study aims to address the existing concerns for mediation meta-analysis (MMA) conducted under pretest-posttest-control-group (PPCG) designs. These issues include the validity of meta-analytic structural equation modeling with a binary independent variable, heterogeneously defined treatment doses, and potential violations of the homogeneous variance assumption. Moreover, an open question remains regarding whether effect sizes in MMA over PPCG designs should be computed from posttest scores (PSMMA) or from pretest-posttest change scores (CSMMA). This study employs theoretical discussions and Monte Carlo simulations to demonstrate the feasibility of MMA under PPCG designs and to compare CSMMA and PSMMA. Furthermore, the procedures for computing effect sizes are summarized, and an empirical example is presented.
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http://dx.doi.org/10.3758/s13428-025-02661-y | DOI Listing |
medRxiv
April 2025
Vancouver Prostate Centre, Vancouver, British Columbia, Canada.
Background: Studies of germline variants in prostate cancer (PCa) have largely focused on their connections to cancer predisposition. However, an understanding of how heritable factors contribute to cancer progression and metastasis remain limited.
Objective: To identify low frequency to rare germline nonsynonymous variants associated with increased risk for metastatic PCa (mPCa), while providing functional validation.
Behav Res Methods
April 2025
Department of Educational Psychology and Learning Systems, College of Education, Florida State University, Tallahassee, USA.
This study aims to address the existing concerns for mediation meta-analysis (MMA) conducted under pretest-posttest-control-group (PPCG) designs. These issues include the validity of meta-analytic structural equation modeling with a binary independent variable, heterogeneously defined treatment doses, and potential violations of the homogeneous variance assumption. Moreover, an open question remains regarding whether effect sizes in MMA over PPCG designs should be computed from posttest scores (PSMMA) or from pretest-posttest change scores (CSMMA).
View Article and Find Full Text PDFClin Gerontol
November 2023
Care Daily Company, Palo Alto, California, USA.
Objectives: Dementia caregivers (CGs) are at heightened risk for developing problems with anxiety and depression. Much attention has been directed toward developing and deploying interventions designed to protect CG health, but few have been supported by rigorous empirical evidence. Technology-based interventions that are effective, scalable, and do not add greatly to the CG burden are of particular interest.
View Article and Find Full Text PDFEur Urol
August 2022
The Institute of Cancer Research, London, UK; The Royal Marsden NHS Foundation Trust, London, UK.
Background: Germline variants explain more than a third of prostate cancer (PrCa) risk, but very few associations have been identified between heritable factors and clinical progression.
Objective: To find rare germline variants that predict time to biochemical recurrence (BCR) after radical treatment in men with PrCa and understand the genetic factors associated with such progression.
Design, Setting, And Participants: Whole-genome sequencing data from blood DNA were analysed for 850 PrCa patients with radical treatment from the Pan Prostate Cancer Group (PPCG) consortium from the UK, Canada, Germany, Australia, and France.
Palliat Med Rep
June 2020
Department of Psychology, Roswell Park Cancer Institute, Buffalo, New York, USA.