98%
921
2 minutes
20
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12020670 | PMC |
http://dx.doi.org/10.1055/a-2573-7598 | DOI Listing |
Med Oncol
September 2025
Division of Hematology and Blood Bank, Department of Medical Laboratory Sciences, School of Paramedical Sciences, Shiraz University of Medical Sciences, Shiraz, Iran.
Acute Myeloid Leukemia (AML) patient-derived Mesenchymal Stem Cells (MSCs) behave differently than normal ones, creating a more protective environment for leukemia cells, making relapse harder to prevent. This study aimed to identify prognostic biomarkers and elucidate relevant biological pathways in AML by leveraging microarray data and advanced bioinformatics techniques. We retrieved the GSE122917 dataset from the NCBI Gene Expression Omnibus and performed differential expression analysis (DEA) within R Studio to identify differentially expressed genes (DEGs) among healthy donors, newly diagnosed AML patients, and relapsed AML patients.
View Article and Find Full Text PDFTissue Eng Regen Med
September 2025
Department of Joint and Sports Medicine, Chaoyang Central Hospital, Chaoyang City, Liaoning Province, China.
Background: Osteoarthritis (OA) represents a major global health challenge with no ideal treatment options available. Early-stage treatment typically focuses on symptomatic relief of pain and stiffness; while late-stage patients can only opt for surgical interventions such as joint replacement to improve quality of life. Cell-free therapy based on extracellular vesicles (EVs) has offered a novel therapeutic approach for regulating bone metabolism and repairing cartilage, demonstrating emerging potential.
View Article and Find Full Text PDFArch Gynecol Obstet
September 2025
Faculty of Medicine, University of Lille, 59000, Lille, France.
Purpose: Endometriosis is a chronic, hormone-dependent disease affecting up to 10% of women of reproductive age, often associated with chronic pelvic pain (CPP). Neuropathic pain has been increasingly recognized as a significant component in a subset of patients with CPP related to endometriosis. The study objective was to assess the prevalence of neuropathic-like pain in women with deep endometriosis (DE) and CPP, and to analyze its influence on pain perception and quality of life.
View Article and Find Full Text PDFInt J Surg
September 2025
Department of Gastrointestinal Surgery, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, Shandong, China.
Aim And Background: This study investigates the impact of D3 lymph node dissection extent on postoperative bowel function and nutritional status in patients undergoing radical surgery for right-sided colon cancer. Given that postoperative diarrhea can significantly affect the quality of life, we examined whether dissection boundaries influence these outcomes.
Methods: This was a prospective, randomized controlled trial conducted at a high-volume tertiary hospital.
J Helminthol
September 2025
Department of Immunology, Parasitology and General Pathology - Laboratory of Experimental Immunoparasitology. https://ror.org/01585b035State University of Londrina, Londrina, Paraná, Brazil.
Strongyloidiasis, caused by , is a neglected parasitic disease and a major global public health issue. This infection exhibits diverse clinical manifestations that, along with the high rates of asymptomatic cases and low-sensitivity diagnostic methods, contribute to the underreporting of the disease. With an estimated 600 million people infected worldwide, this disease is particularly prevalent in tropical and subtropical regions with poor sanitary conditions, which includes Brazil.
View Article and Find Full Text PDF