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Clinical blood pump consoles for extracorporeal membrane oxygenation (ECMO) are poorly accessible to researchers due to their high cost. Furthermore, clinical machines are built and designed at a high level of information security, which limits their integration with third-party machines and software. These barriers hinder researchers from customizing blood pump consoles for their investigational needs, limiting innovations and advancements in the areas of blood pump automation and pulsation. To address these needs, we present on a programmable Smart Blood Pump console. This console can be assembled for under $200 and uses open-source tools including Arduino. Using this console, centrifugal blood pump heads can be operated at clinically relevant levels of flow and pressure needed in extracorporeal life support applications (>250 mmHg pressure head, >4 L/min of blood flow). Additionally, the programmable nature allows for utility beyond the standard indications of clinical extracorporeal blood pumps, including pulsatility and servo control. For future directions, this console will be further developed to accommodate a wider range of clinical pump heads. We envision that this will be an affordable, open-access platform to suit the varying needs of engineers and researchers for fostering innovations in ECMO technology.
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http://dx.doi.org/10.1016/j.ohx.2025.e00644 | DOI Listing |
Ann Biomed Eng
September 2025
Department of Mechanical Engineering, Koc University, Rumeli Feneri Campus, Sarıyer, 34450, Istanbul, Turkey.
Purpose: The design and development of ventricular assist devices have heavily relied on computational tools, particularly computational fluid dynamics (CFD), since the early 2000s. However, traditional CFD-based optimization requires costly trial-and-error approaches involving multiple design cycles. This study aims to propose a more efficient VAD design and optimization framework that overcomes these limitations.
View Article and Find Full Text PDFNaunyn Schmiedebergs Arch Pharmacol
September 2025
Department of Hematology, The Seventh Affiliated Hospital, Sun Yat-Sen University, Shenzhen, 518107, China.
Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy but are increasingly linked to immune-related kidney injury (irKI). This study presents the first bibliometric analysis of irKI research (2000-2025), aiming to identify key trends, mechanistic insights, and pharmacological risk factors. We analyzed 2,179 publications to understand the evolution of irKI research, focusing on areas like T cell-mediated tubular injury, immune system-driven inflammation, and changes in metabolism.
View Article and Find Full Text PDFG Ital Nefrol
August 2025
Infermiere Professionale SSD Nefrologia e Dialisi P.O. Soverato, ASP CZ.
Management of diabetes mellitus in hemodialysis is highly complex due to increased glycemic variability and hypoglycemic risk. The use of technologies applied to diabetes has been shown to improve glycemic control, however data in dialysis patients are limited. To describe the efficacy and safety of the minimed 780G AHCL system in a stable hemodialysis patient and during hospitalization in the Intensive Care Unit (ICU).
View Article and Find Full Text PDFACS Infect Dis
September 2025
Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas 75390, United States.
Malaria treatments are compromised by drug resistance, creating an urgent need to discover new drugs. We used a phenotypic high-throughput screening (HTS) platform to identify new antimalarials, uncovering three related pyrrole-, indole-, and indoline-based series with a shared α-azacyclic acetamide core. These compounds showed fast-killing activity on asexual blood-stage parasites, were not cytotoxic, and disrupted parasite intracellular pH and Na regulation similarly to cipargamin (KAE609), a clinically advanced inhibitor of the Na pump (ATP4).
View Article and Find Full Text PDFScience
September 2025
Center for Systems Biology, Massachusetts General Hospital and Harvard Medical School, Boston, MA, USA.
Ventricular tachycardia disrupts the heart's coordinated pump function, leading to sudden cardiac death. Neutrophils, which are recruited in high numbers to the ischemic myocardium, promote these arrhythmias. Comparing neutrophils with macrophages, we found that resistin-like molecule γ ( or RELMγ) was the most differentially expressed gene in mouse infarcts.
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