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Percutaneous Left Atrial Appendage Occlusion (LAAO) has emerged as a promising intervention for stroke prevention in patients with atrial fibrillation who are contraindicated for long-term anticoagulation therapy. Despite its growing adoption, a comprehensive review of the LAAO procedure is essential to consolidate the supporting evidence, identify limitations, and outline future directions. This review aims to evaluate the efficacy and safety of LAAO, drawing on clinical trials and real-world studies to provide a balanced perspective. Additionally, we address the limitations of current research, including variability in patient selection, procedural techniques, and follow-up protocols. By highlighting gaps in the knowledge and areas for improvement, this review aims to guide future research efforts to optimize and expand the therapeutic potential of LAAO.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11989772 | PMC |
http://dx.doi.org/10.3390/jcm14072300 | DOI Listing |
Cardiovasc Interv Ther
September 2025
Division of Cardiovascular Medicine, Toyohashi Heart Center, Aichi, Japan.
The outcome of percutaneous coronary intervention (PCI) compared to coronary artery bypass grafting (CABG) is still controversial for patients with left main coronary artery (LMCA) disease. This multicenter cohort study aimed to evaluate the clinical outcomes of LMCA disease patients who underwent PCI or CABG. We reviewed 875 consecutive patients diagnosed with LMCA disease between January 2009 and December 2020 who underwent coronary revascularization by PCI (n = 404) or CABG (n = 471).
View Article and Find Full Text PDFJ Thromb Thrombolysis
September 2025
Faculty of Medicine, Kafrelsheikh University, Kafrelsheikh, Egypt.
In this review, we aimed to evaluate Sonothrombolysis when combined with primary percutaneous coronary intervention (pPCI) in STEMI patients with regard to improving cardiac function and clinical outcomes. This study primarily assesses short-term efficacy outcomes, while long-term impacts, such as mortality, were not evaluated. Following the PRISMA (Preferred Reporting Items for Systematic Reviews and Meta-Analyses) guidelines, we searched four electronic databases (PubMed, Scopus, Cochrane Library, and Web of Science) to identify eligible studies reported up to November 2024.
View Article and Find Full Text PDFMedicine (Baltimore)
September 2025
Anesthesiology Department, Southern Central Hospital of Yunnan Province (First People's Hospital of Honghe State), Mengzi, Yunnan Province, China.
Rationale: Ureteral stricture is a complex urological condition often requiring surgical intervention. Autologous tissue grafts, such as lingual mucosa, have emerged as a promising option for reconstruction due to their favorable biocompatibility and vascularity. However, reports on complications associated with these techniques remain limited.
View Article and Find Full Text PDFSurg Radiol Anat
September 2025
Orthopaedics and Traumathology Department, ULS São João, Porto, Portugal.
Purpose: Pelvic ring fractures involving the iliopubic rami can cause functional impairment. Percutaneous retrograde fixation is a less invasive procedure when compared to traditional open approaches, however precise anatomical knowledge is crucial for safe screw placement. This study aims to describe the morphology of the iliopubic rami, define a safety corridor for percutaneous screw fixation, specially focusing on the relationships between the iliopubic rami and neurovascular structures.
View Article and Find Full Text PDFCureus
August 2025
Physiology, Alkindy College of Medicine, Baghdad University, Baghdad, IRQ.
Cor triatriatum is a rare congenital heart defect that divides the right or left atrium into three chambers. Although the diagnosis is typically made within the first years of birth, it can occasionally be made later in adulthood and is frequently associated with other cardiac defects but may be present in isolation. Clinical manifestations range from lung congestion, exhaustion, coughing, and dyspnea to the onset of heart failure.
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