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Following the experimental medicine approach, Diehl et al. (2023) demonstrated the malleability of negative views of aging (NVOA), self-efficacy beliefs, and exercise intention in middle-aged and older adults who participated in the AgingPLUS intervention program. The present study built on those findings and addressed (a) whether the intervention resulted in significant improvements in physical activity (PA) and (b) whether the purported mechanistic variables were significant mediators of the intervention's effects on PA outcomes. AgingPLUS used a randomized, single-blind control group design to implement the intervention in a sample of 335 adults aged 45-75 years. This study reports findings from 278 participants ( = 60.1 years; = 8.3 years) for whom PA measures were available at baseline and the delayed posttest at Week 8. Compared to participants in the Health Education control group and compared to baseline, participants in the AgingPLUS program showed significant improvements in accelerometer-assessed PA (e.g., total daily steps walked; total daily minutes of moderate-to-vigorous PA [MVPA]) and self-reported PA (e.g., weekly kcals burned in MVPA; increase in weekly total minutes of MVPA). Findings from bias-corrected bootstrap mediation analyses yielded partial support for the purported mechanisms of the intervention. Specifically, improvements in NVOA mediated the effects of the intervention on several accelerometer-assessed PA outcomes. Furthermore, improvements in NVOA, general, motivational, and volitional self-efficacy beliefs were significant mediators on several self-reported PA outcomes. Overall, findings provided support for small but significant effects of AgingPLUS on PA outcomes and supportive evidence for several of the theoretical mechanisms tested. (PsycInfo Database Record (c) 2025 APA, all rights reserved).
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http://dx.doi.org/10.1037/pag0000893 | DOI Listing |
J Ethnopharmacol
September 2025
Pingshan Hospital, Southern Medical University, Shenzhen, Guangdong 518118, P.R. China; Pingshan District Peoples' Hospital of Shenzhen, Shenzhen, Guangdong 518118, P.R. China; School of Traditional Chinese Medicine, Southern Medical University, Guangzhou, Guangdong 510515, China. Electronic address
Ethnopharmacological Relevance: Dingxin Recipe III (DXRIII) is a traditional Chinese medicinal formulation that has been employed in clinics for over two decades. It is utilized in the treatment of cardiovascular diseases associated with atherosclerosis (AS) through mechanisms purported to involve the clearing of heat and detoxification, as well as the promotion of blood circulation and the removal of blood stasis. Despite its widespread application and reported therapeutic benefits, its exact mechanisms remain incompletely elucidated.
View Article and Find Full Text PDFhas long been used in folk medicine to treat a variety of ailments, including diabetes, skin disorders, dropsy, cuts, wounds, ulcers, fever, and blood disorders, etc., which are generally categorized under the complications of diabetes mellitus. Various species of this genus have also been verified to possess strong anti-diabetic activity.
View Article and Find Full Text PDFBiol Psychol
August 2025
Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, 630 West 168th St., Presbyterian Hospital Suite 1540, New York, NY 10032, United States. Electronic address:
The concept of self regulation has been of interest to psychologists for decades, and physiological mechanisms that underpin self regulatory ability are of clinical interest. Two mechanistic theories have been proposed: the polyvagal theory (PVT) and neurovisceral integration model (NVIM), each assuming vagus nerve activity to be a readout of self regulatory capacity. This paper critically examines the extant research that identifies purported associations between self-regulation and cardiac activity, confusion around constructs, misleading claims about the relationship between HF-HRV/RSA and vagal activity, methodological problems, errors in neuroanatomy, contradictory findings, and lack of consideration of social context and resource availability in defining effective self-regulation behaviors.
View Article and Find Full Text PDFPLoS One
August 2025
Deparment of Pharmacology and Physiology, Saint Louis University School of Medicine, St. Louis, MO, USA.
Cannabidiol (CBD) has gained a lot of interest in recent years for its purported medicinal properties. CBD has been investigated for the treatment of anxiety, depression, epilepsy, neuroinflammation, and pain. Recently there has been an interest in CBD as a possible treatment for age-related disorders such as Alzheimer's disease and related disorders (ADRD).
View Article and Find Full Text PDFbioRxiv
August 2025
Department of Chemistry and Biochemistry, University of California, San Diego, La Jolla, CA, 92093 USA.
The major bacterial pathogen (Group A or Strep A) recruits the negative regulator of the alternative complement pathway factor H (FH) to its surface. Antigenically sequence variable regions of several Strep A M proteins, including M5 and M6, bind FH but have no obvious sequence homology. A second Strep A surface-localized protein, FbaA, binds FH through a purported coiled-coil region, suggesting mimicry of the well-known coiled coil of M proteins.
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