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Purpose: Metal artifacts remain a persistent issue in intraoperative CBCT imaging. Particularly in orthopedic and trauma applications, these artifacts obstruct clinically relevant areas around the implant, reducing the modality's clinical value. Metal artifact avoidance (MAA) methods have shown potential to improve image quality through trajectory adjustments, but often fail in clinical practice due to their focus on irrelevant objects and high computational demands. To address these limitations, we introduce the novel parametric metal artifact avoidance (P-MAA) method.
Methods: The P-MAA method first detects keypoints in two scout views using a deep learning model. These keypoints are used to model each clinically relevant object as an ellipsoid, capturing its position, extent, and orientation. We hypothesize that fine details of object shapes are less critical for artifact reduction. Based on these ellipsoidal representations, we devise a computationally efficient metric for scoring view trajectories, enabling fast, CPU-based optimization. A detection model for object localization was trained using both simulated and real data and validated on real clinical cases. The scoring method was benchmarked against a raytracing-based approach.
Results: The trained detection model achieved a mean average recall of 0.78, demonstrating generalizability to unseen clinical cases. The ellipsoid-based scoring method closely approximated results using raytracing and was effective in complex clinical scenarios. Additionally, the ellipsoid method provided a 33-fold increase in speed, without the need for GPU acceleration.
Conclusion: The P-MAA approach provides a feasible solution for metal artifact avoidance in CBCT imaging, enabling fast trajectory optimization while focusing on clinically relevant objects. This method represents a significant step toward practical intraoperative implementation of MAA techniques.
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http://dx.doi.org/10.1007/s11548-025-03348-7 | DOI Listing |
Thromb Res
September 2025
Center for Thrombosis and Hemostasis, University Medical Center of the Johannes Gutenberg University, Mainz, Germany. Electronic address:
Warfarin is a widely used vitamin K antagonist (VKA) with known pleiotropic effects beyond anticoagulation. Preclinical and case-control evidence suggests that warfarin may affect hematopoiesis, but longitudinal human evidence is lacking. To explore this potential effect, we conducted a post-hoc analysis of participants in the Hokusai-VTE and ENGAGE AF-TIMI 48 trials, which randomized patients to warfarin or the direct oral anticoagulant edoxaban with routine laboratory testing at predefined follow-up visits.
View Article and Find Full Text PDFJ Med Internet Res
September 2025
Center for Healthy Minds and Department of Counseling Psychology, University of Wisconsin-Madison, Madison, WI, United States.
Background: Ecological momentary assessment (EMA) is increasingly being incorporated into intervention studies to acquire a more fine-grained and ecologically valid assessment of change. The added utility of including relatively burdensome EMA measures in a clinical trial hinges on several psychometric assumptions, including that these measure are (1) reliable, (2) related to but not redundant with conventional self-report measures (convergent and discriminant validity), (3) sensitive to intervention-related change, and (4) associated with a clinically relevant criterion of improvement (criterion validity) above conventional self-report measures (incremental validity).
Objective: This study aimed to evaluate the reliability, validity, and sensitivity to change of conventional self-report versus EMA measures of rumination improvement.
Chem Biodivers
September 2025
Department of Clinical Pharmacy, College of Pharmacy, University of Sulaimani, Sulaimani, Iraq.
The global rise in antibiotic resistance demands the urgent development of new antibacterial agents. This study investigated the antibacterial potential of four synthesized methoxy and thiophene chalcone derivatives (designated 3a, 4a, 3b, and 4b) against clinically relevant bacterial pathogens. These compounds were prepared through Claisen-Schmidt condensation, while their chemical structures were verified through applying Fourier-transform infrared, mass spectrometry, H nuclear magnetic resonance (NMR), and C NMR.
View Article and Find Full Text PDFCrit Care Explor
September 2025
Department of Biostatistics, University of Florida Colleges of Medicine and Public Health and Health Professions, Gainesville, FL.
Objectives Background: Monocyte anisocytosis (monocyte distribution width [MDW]) has been previously validated to predict sepsis and outcome in patients presenting in the emergency department and mixed-population ICUs. Determining sepsis in a critically ill surgical/trauma population is often difficult due to concomitant inflammation and stress. We examined whether MDW could identify sepsis among patients admitted to a surgical/trauma ICU and predict clinical outcome.
View Article and Find Full Text PDFCrit Care Explor
September 2025
Division of Tropical Medicine and Infectious Diseases, Department of Internal Medicine, Dr. Cipto Mangunkusumo National General Hospital, Faculty of Medicine Universitas Indonesia, Jakarta, Indonesia.
Importance: Sepsis remains a leading cause of death in infectious cases. The heterogeneity of immune responses is a major challenge in the management and prognostication of patients with sepsis. Identifying distinct immune response subphenotypes using parsimonious classifiers may improve outcome prediction, particularly in resource-limited settings.
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