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Food fraud raises significant concerns to consumer health and economic integrity, with the adulteration of honey by sugary syrups representing one of the most prevalent forms of economically motivated adulteration. This study presents a novel framework that combines data from multiple analytical techniques with specialized deep learning models (convolutional neural networks), integrated via meta-learning, in order to differentiate between pure honey and samples adulterated with sugar cane molasses, glucose syrup, or caramel-flavored ice cream topping. Unlike traditional chemometric methods, this approach expands the input feature space, leading to enhanced predictive performance. The resulting deep heterogeneous ensemble learner exhibited considerable generalization capability, achieving an average classification accuracy of 98.53 % and a Matthews correlation coefficient of 0.9710. Furthermore, the ensemble demonstrated exceptional robustness, maintaining an accuracy of 73 %, even when 90 % of the input data were corrupted, underscoring its unparalleled capacity to generalize under both subtle and extreme data variability. This adaptable and scalable solution underscores the transformative potential of ensemble-meta-learning strategy for addressing complex challenges in analytical chemistry. The model, its constituents and other additional resources were made available in an open repository.
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http://dx.doi.org/10.1016/j.foodchem.2025.144001 | DOI Listing |
Trends Genet
August 2025
Novo Nordisk Foundation Center for Basic Metabolic Research, University of Copenhagen, Copenhagen, Denmark. Electronic address:
Complex diseases are heterogeneous and evolve along a continuum, limiting individual-level prediction with current approaches. The Human Phenotype Project (HPP) integrates deep phenotyping with generative artificial intelligence (AI) to identify early deviations in health parameters. While the project has already provided significant insights, the challenge is converting these findings into actionable, equitable, and scalable interventions, advancing precision healthcare across diverse populations.
View Article and Find Full Text PDFJ Immunother Cancer
September 2025
CAS Key Laboratory of Molecular Imaging, Institute of Automation, Chinese Academy of Sciences, Beijing, China
Neoadjuvant immunochemotherapy (nICT) has demonstrated significant potential in improving pathological response rates and survival outcomes for patients with locally advanced esophageal squamous cell carcinoma (ESCC). However, substantial interindividual variability in therapeutic outcomes highlights the urgent need for more precise predictive tools to guide clinical decision-making. Traditional biomarkers remain limited in both predictive performance and clinical feasibility.
View Article and Find Full Text PDFEur J Radiol
September 2025
Department of Radiology, Affiliated Hospital of Hebei University, Baoding 071000, China. Electronic address:
Purpose: The present study aimed to develop a noninvasive predictive framework that integrates clinical data, conventional radiomics, habitat imaging, and deep learning for the preoperative stratification of MGMT gene promoter methylation in glioma.
Materials And Methods: This retrospective study included 410 patients from the University of California, San Francisco, USA, and 102 patients from our hospital. Seven models were constructed using preoperative contrast-enhanced T1-weighted MRI with gadobenate dimeglumine as the contrast agent.
Sci Adv
September 2025
Department of Environmental Science, Stockholm University, Stockholm, Sweden.
Organic matter stored in Arctic permafrost represents a key component of the carbon cycle, yet its reactivity across heterogeneous continent-scale permafrost regions remains poorly understood. Here, we leverage the four shelf seas of the Eurasian Arctic as integrative receptor systems to evaluate terrestrial organic matter reactivity, assessed by examining organic carbon preservation as a function of C-constrained cross-shelf transport time. Our findings reveal higher reactivity of terrestrial organic matter released to the Laptev Sea and the eastern East Siberian Sea, lower reactivity in the western East Siberian Sea, and no deducible degradation in the Kara Sea.
View Article and Find Full Text PDFBioinformatics
September 2025
Computational Health Center, Helmholtz Center Munich, Neuherberg, 85764, Germany.
Motivation: Recent pandemics have revealed significant gaps in our understanding of viral pathogenesis, exposing an urgent need for methods to identify and prioritize key host proteins (host factors) as potential targets for antiviral treatments. De novo generation of experimental datasets is limited by their heterogeneity, and for looming future pandemics, may not be feasible due to limitations of experimental approaches.
Results: Here we present TransFactor, a computational framework for predicting and prioritizing candidate host factors using only protein sequence data.