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Background: Heart failure (HF) is associated with significant mortality and morbidity and accounts for substantial health care resources. We examined hospitalization costs of patients with HF in Canada (excluding patients from Quebec and the Territories) between 2010/2011 and 2018/2019 and estimated future costs to 2039/2040.
Methods: We identified hospitalization records with a primary diagnosis of HF between 2010/2011 and 2018/2019. Concurrent hospitalizations were combined to identify episodes of care. Total hospitalization costs and costs per HF patient were calculated for each fiscal year of the study. All costs are presented in 2022 CAD$. Generalized linear models were used to project primary HF hospitalization episodes and costs to 2039/2040 on the basis of population projections from Statistics Canada.
Results: There were 436,160 hospitalization episodes with a primary diagnosis of HF. Between 2010/2011 and 2018/2019, HF episodes increased from 43,114 to 54,743, and number of patients increased from 34,960 to 44,567, and total hospitalization costs increased from $684.3 million to $776.0 million, resulting in a cumulative cost of $6.65 billion. Between 2019/2020 and 2039/2040, there are projected to be 1.69 million HF hospitalization episodes, costing the Canadian health care system $19.5 billion.
Conclusions: HF places a substantial economic burden on the Canadian health care system, which is likely to increase in the coming decades. Health system planning and policy solutions to identify, and reduce barriers to, HF therapies that are effective in preventing hospitalizations; and improved access to community-based services are needed to mitigate future costs.
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http://dx.doi.org/10.1016/j.cjco.2024.11.019 | DOI Listing |
J Environ Pathol Toxicol Oncol
January 2025
The Hippo pathway and its transcription co-activator YAP play a critical role in the regulation of cell proliferation, apoptosis and the control of organ size. In the past several years, YAP has been found to be expressed in various human cancers, however, its expression in Nasopharyngeal Carcinoma (NPC) remains unstudied. In this report, we found that YAP was overexpressed in human NPC tissues, and its expression was also significantly higher in five NPC cell lines when compared with the nasopharyngeal epithelial cell line NP69 (P < 0.
View Article and Find Full Text PDFMult Scler Relat Disord
September 2025
Department of Psychology, Wayne State University, Detroit, MI, 48202, USA; Institute of Gerontology, Wayne State University, Detroit, MI, 48202, USA; Translational Neuroscience Program, Wayne State University, Detroit, MI, 48201, USA. Electronic address:
The ability to navigate through one's environment is crucial for maintaining independence in daily life and depends on complex cognitive and motor functions that are vulnerable to decline in persons with Multiple Sclerosis (MS). While previous research suggests a role for mobility in the physical act of navigation, it remains unclear to what extent mobility impairment and perceptions of mobility constraints may modify wayfinding and the recall of environment details in support of successful navigation. Therefore, this study examined the relations among clinical mobility function, concern about falling, and recall of environment details in a clinical sample of MS.
View Article and Find Full Text PDFInt J Law Psychiatry
September 2025
Wolfson Institute of Population Health, Centre for Psychiatry and Mental Health, Queen Mary University of London, UK. Electronic address:
Individuals with mental health difficulties in Iceland can be detained in police cells as a last resource place of safety when psychiatrists consider patients unsuitable for admission to a ward, for example, due to being under the influence of substances or being too violent. We aimed to investigate if detainment in a police cell affected symptoms of mental illnesses, and subsequently if police cells are an appropriate place of safety for patients in Iceland. We used a mixed methods approach utilising administrative records of detainees' visible symptoms of mental illnesses and ten semi-structured interviews with mental health professionals and police sergeants.
View Article and Find Full Text PDFInt J Law Psychiatry
September 2025
School of Law, University of Edinburgh, Old College, South Bridge, Edinburgh EH8 9YL, United Kingdom. Electronic address:
The Mental Health Act 1983 (MHA) authorizes the compulsory detention and treatment of people with mental disorders who are perceived to pose a risk to themselves or to others. Since its enactment, there have been concerns that the coercive powers of the Act have been disproportionately used for Black people with mental disorders. This disproportionate impact of the MHA on Black people is most clearly seen in the excessive use of Community Treatment Orders (CTOs).
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