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The generation of optical vortices in compact systems and across different spectral regions can open new horizons for their applications in end-user devices. Latest advances in the design and fabrication of optical metasurfaces made of a quadratically nonlinear material enable highly precise creation of vortices with different topological charges at the second-harmonic frequency, with the potential to obtain various other structured states of light.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11965502 | PMC |
http://dx.doi.org/10.1038/s41377-025-01831-z | DOI Listing |
J Adv Nurs
September 2025
Department of Sociology and Behavioral Sciences, De La Salle University, Manila, Philippines.
Aim: To explore the potential axiological shift in nursing, drawing upon a critical reading of the new definition of 'nursing' published by the International Council of Nurses (ICN) in June 2025, and to articulate its implications for research and doctoral education.
Design: Critical discussion paper.
Methods: Guided by critical inquiry and emancipatory nursing knowledge development approaches, this paper deploys retroductive analysis to interrogate the axiological commitments that inform and are generated by the 2025 ICN definition and how it relates to nursing research.
Mater Horiz
September 2025
TU Delft, Netherlands.
Soft wearable sensors offer promising potential for advanced diagnostics, therapeutics, and human-machine interfaces. Unlike conventional devices that are bulky and rigid, often compromising skin integrity, comfort, and user compliance, soft wearable sensors are flexible, conformable, and better suited to the dynamic skin surface. This improved mechanical integration enhances signal fidelity and device performance, while also enabling safer, more comfortable, and continuous physiological monitoring in real-world environments.
View Article and Find Full Text PDFStroke
September 2025
Department of Neurology, Yale School of Medicine, New Haven, CT (L.H.S.).
Preclinical stroke research faces a critical translational gap, with animal studies failing to reliably predict clinical efficacy. To address this, the field is moving toward rigorous, multicenter preclinical randomized controlled trials (mpRCTs) that mimic phase 3 clinical trials in several key components. This collective statement, derived from experts involved in mpRCTs, outlines considerations for designing and executing such trials.
View Article and Find Full Text PDFChild Care Health Dev
September 2025
Department of Behavioral Sciences and Learning, Linköping University, Linköping, Sweden.
Objective: To describe the self-report instruments used to measure well-being in children with disabilities, investigate their psychometric quality, cognitive accessibility and alignment with Keyes's operationalization of well-being, including emotional, psychological and social aspects.
Methods: MEDLINE, ProQuest, PubMed and CINAHL were searched for articles published from 2011 to March 2023, identifying 724 studies. Synonyms provided by thesaurus on the main constructs: 'children', 'measure', 'disability' and 'mental health' were employed in the search strategy.
Lab Chip
September 2025
Weldon School of Biomedical Engineering, Purdue University, West Lafayette, IN 47907, USA.
Traumatic brain injuries (TBIs) are a risk factor for Alzheimer's disease (AD), and share several important pathological features including the development of neurofibrillary tangles (NFT) of tau protein. While this association is well established, the underlying pathogenesis is poorly defined and current treatment options remain limited, necessitating novel methods and approaches. In response we developed "TBI-on-a-chip", an trauma model utilizing murine cortical networks on microelectrode arrays (MEAs), capable of reproducing clinically relevant impact injuries while providing simultaneous morphological and electrophysiological readout.
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