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http://dx.doi.org/10.1038/s41375-025-02587-6 | DOI Listing |
J Am Heart Assoc
September 2025
Institute for Clinical Diabetology, German Diabetes Center Leibniz Center for Diabetes Research at Heinrich Heine University Düsseldorf Düsseldorf Germany.
Background: We sought to investigate the association between circulating inflammatory and cardiovascular proteomics biomarkers and cardiac autonomic nervous dysfunction-sensitive heart rate variability indices.
Methods: Using the population-based KORA (Cooperative Health Research in the Region of Augsburg) cohort, 233 proteomics biomarkers were quantified in baseline plasma samples of 1389 individuals using proximity extension assay technology. Five heart rate variability indices (Rényi entropy of the histogram with order [α] 4, total power of the density spectra, SD of word sequence, SD of the short-term normal-to-normal interval variability, compression entropy) were assessed at baseline in 982 individuals and in 407 individuals at baseline and at 14-year follow-up.
Bone
September 2025
Department of Anesthesiology, Critical Care and Pain Medicine, Boston Children's Hospital, Harvard Medical School, Boston, MA, USA; Department of Psychiatry, McLean Hospital, Harvard Medical School, Belmont, MA, USA. Electronic address:
Pain in Fibrous dysplasia/McCune-Albright syndrome (FD/MAS) remains poorly understood and inadequately managed due to uncertainties regarding clinical or biological drivers. This cross-sectional pilot study aimed to use plasma proteomics to identify markers that inform on molecular pathways associated with pain and emotional symptoms in FD/MAS. Seventeen individuals (15 females, 2 males), aged 16 to 63 years, with confirmed diagnoses of monostotic FD, polyostotic FD, or MAS participated in a single study visit conducted at Boston Children's Hospital and Massachusetts General Brigham.
View Article and Find Full Text PDFClin Nutr
August 2025
Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
Background & Aims: Circulating proteins are integral to many biological processes and could be influenced by diet. We aimed to assess differences in the plasma proteome between people of different dietary groups, defined by degree of animal food consumption.
Methods: The UK Biobank recruited middle-aged adults (mostly 40-69 years) throughout the UK between 2006 and 2010.
J Agric Food Chem
September 2025
School of Food Science & Nutrition, University of Leeds, Leeds LS2 9JT, U.K.
This study evaluated the nutritional and antinutritional (ANFs) composition and protein profiles of different components of Ramon () seed, including the seed coat, fruit, and both roasted and green (unprocessed) seeds. Proximate composition, mineral content, ANFs quantification, amino acid profile, protein digestibility, SDS-PAGE, proteomics, and gluten ELISA were performed. Protein contents ranged from 9.
View Article and Find Full Text PDFJ Proteome Res
September 2025
Metabolomics and Proteomics Core, Helmholtz Zentrum München, German Research Center for Environmental Health, 80939 Munich, Germany.