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Background: Decentralizing HIV services is an evidence-based strategy recommended by the World Health Organization to expand healthcare access by shifting most HIV care from specialty (SHCs) to primary health centers (PHCs) with the goal of maximizing health outcomes. To accelerate Peru Ministry of Health's 2020 priority to transition from specialty to primary health centers, we assessed multilevel stakeholders' perspectives on barriers and opportunities for scaling-up decentralization of HIV care.
Methods: Between January and March 2024, we used nominal group technique (NGT), a mixed-methods research strategy, to rapidly identify barriers and rank potential solutions to decentralizing HIV services among two groups of patients (N = 16) and four groups of healthcare providers (N = 49) in Lima, Peru. Patient groups were those who: (1) were established in HIV care at a SHC; and (2) transferred from a SHC to a PHC. Three provider groups were mixed and included individuals from PHCs and SHCs while one was from a SHC in Central Lima. After listing all perceived barriers and solutions, participants in each group rank-ordered responses to generate potentially actionable responses.
Results: Among 195 votes from 65 participants, multilevel HIV stigma was the highest priority barrier to decentralizing HIV care among both patients and providers (34.4%). While patients and providers prioritized different issues, all NGT groups highlighted a general lack of confidence in the expertise of PHCs (21.0%), system-level or transfer logistic challenges (19.0%), insufficient infrastructure and capacity of PHCs to provide HIV treatment (15.9%), and a lack of patient-level support (9.7%) as other major barriers to HIV decentralization.
Conclusions: While the Peruvian Ministry of Health has prioritized HIV care decentralization, achieving this goal remains challenging. Identified barriers require a range of implementation strategies to achieve decentralization goals, such as process improvement strategies to address stigma and logistical barriers to transferring patients, while educational meetings, including tele-mentoring or expert feedback, may address a lack of confidence in provider expertise at PHCs. Deployment of hub-and-spoke treatment models could enhance communication between experts at SHCs and PHCs and ensure that patient continuity of care is achieved.
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http://dx.doi.org/10.1186/s12913-025-12618-8 | DOI Listing |
PLoS One
September 2025
School of Public Health, College of Health Sciences, Makerere University, Kampala, Uganda.
Background: Despite advances in HIV care, viral load suppression (VLS) among adolescents living with HIV (ALHIV) in Uganda continue to lag behind that of adults, even with the introduction of dolutegravir (DTG)-based regimens, the Youth and Adolescent Peer Supporter (YAPS) model, and community-based approaches. Understanding factors associated with HIV viral load non-suppression in this population is critical to inform HIV treatment policy. This study assessed the prevalence and predictors of viral load non-suppression among ALHIV aged 10-19 years on DTG-based ART in Soroti City, Uganda.
View Article and Find Full Text PDFPLoS One
September 2025
Centre for Experimental Pathogen Host Research, School of Medicine, University College Dublin, Dublin, Ireland.
Background: Acute viral respiratory infections (AVRIs) rank among the most common causes of hospitalisation worldwide, imposing significant healthcare burdens and driving the development of pharmacological treatments. However, inconsistent outcome reporting across clinical trials limits evidence synthesis and its translation into clinical practice. A core outcome set (COS) for pharmacological treatments in hospitalised adults with AVRIs is essential to standardise trial outcomes and improve research comparability.
View Article and Find Full Text PDFJ Int Assoc Provid AIDS Care
September 2025
Department of Internal medicine, School of Medicine, College of Medicine and Health Sciences, University of Gondar, Gondar, Ethiopia.
BackgroundDolutegravir (DTG)-based antiretroviral treatment is now the recommended regimen because of its high efficacy and fewer adverse effects. Nonetheless, hyperglycemia as adverse effect of DTG was reported in few clinical observations.MethodsA case-control study was carried out among DTG-based antiretroviral therapy (ART) users during the study period.
View Article and Find Full Text PDFInt J STD AIDS
September 2025
Centre for Communicable Diseases Control and Research, Federal Medical Centre, Asaba, Nigeria.
BackgroundMother-to-Child Transmission (MTCT) of HIV continues to be a critical public health issue, particularly in high-prevalence regions. This study examines the rates of MTCT in relation to antenatal booking, parity, antiretroviral (ARV) use, delivery mode, CD4 counts, and infant feeding practices.MethodsA retrospective cross-sectional study was conducted at the Federal Medical Centre, Asaba, Nigeria, involving pregnant women living with HIV attending the Prevention of Mother-to-Child Transmission (PMTCT) program.
View Article and Find Full Text PDFPersistent high-risk human papillomavirus (hHPV) infection, especially HPV-16, plays a central role in the development of high-grade squamous intraepithelial lesions (HSIL). This study aimed to evaluate the performance of co-testing (cytology and hHPV detection) in a real-world cohort of men who have sex with men (MSM) and transgender women (TW) living with HIV. We conducted a prospective study (2017-2023) at a tertiary care center in Spain.
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