Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
We studied the processes of cell death and intracellular accumulation of free radicals, as well as activity of redox-sensitive transcription factors Nrf2 and NF-κB under the action of nitrosyl iron complex with N-ethylthiourea (ETU) on a model of human mesenchymal stem cells in vitro. ETU complex exhibits a pronounced prooxidant and cytotoxic effects accompanied by enhanced intracellular accumulation of nitrogen monoxide, induction of apoptotic cell death, activation of Nrf2/HO-1 pathways, and suppression of proinflammatory NF-κB-mediated reactions. A significant role of redox-dependent cellular processes in the mechanisms of the cytotoxic effect of nitrosyl iron complexes is shown.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s10517-025-06367-1 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Multifunctional Hybrid Membrane-Coated Nanomotors for Magnetically Guided, Cascade-Activated Chemoimmunotherapy for Triple-Negative Breast Cancer.
ACS Appl Mater Interfaces
September 2025
Department of Chemistry, The Chinese University of Hong Kong, Shatin, Hong Kong SAR 999077, China.
Here, we report a multifunctional hybrid membrane-coated nanomotor for cancer chemoimmunotherapy, which consists of mesoporous silica-coated iron oxide nanoparticles (MF) as a drug carrier, loaded with doxorubicin (DOX), l-arginine (l-arg), and glucose oxidase (GOx), and camouflaged with a hybrid of red blood cell membranes (mRBC) and cancer cell membranes (CCM). RM-GDL-MF has a cascade of catalytic reactions, where glucose is catalyzed by GOx to produce HO, and l-arg is oxidized by the produced HO to release nitric oxide (NO), leading to self-propelled motion in order to promote the penetration of the extracellular matrix (ECM) in the tumor. The hybrid membrane provides not only stealth properties from mRBC to evade immune clearance but also tumor-orientation ability to target the tumor from the CCM.
View Article and Find Full Text PDFInterplay of oxidative stress and antioxidant mechanisms in cancer development and progression.
Arch Toxicol
September 2025
Faculty of Chemical and Food Technology, Slovak University of Technology, 812 37, Bratislava, Slovakia.
Cellular systems responsible for the formation and removal of reactive oxygen species (ROS), functioning within physiological limits, are essential for maintaining intracellular redox balance. This state is known as oxidative eustress. Key redox signaling molecules, such as superoxide anion radical (O) and hydrogen peroxide (HO), operate at nanomolar concentrations and are produced by NADPH oxidases (regulated by various factors), the mitochondrial electron transport chain (ETC), and numerous enzymes.
View Article and Find Full Text PDFIdentification, Quantification, and Antioxidant Evaluation of Phenolic Compounds from Colored (L.) Roots Using UHPLC-DAD-ESI-MS/MS.
Antioxidants (Basel)
August 2025
Laboratorio de Desarrollo de Bioprocesos Sostenibles (Labisost), Escuela de Agronomía, Facultad de Ciencias Agronómicas y de los Alimentos, Pontificia Universidad Católica de Valparaíso, Casilla 4-D, Quillota 2260000, Chile.
This study investigates the phenolic composition and antioxidant potential of root extracts from three varieties (green, red, and orange) using ultra-high-performance liquid chromatography coupled with diode array detection and electrospray ionization-tandem mass spectrometry (UHPLC-DAD-ESI-MS/MS). Phenolic compounds were extracted with a hydromethanolic solvent and quantified by spectrophotometric assays, while antioxidant activity was assessed through DPPH, ABTS, iron III reduction, hydroxyl radical, and nitric oxide scavenging methods. A total of 26 compounds were identified, including piscidic acid, epicatechin-3--gallate, and isovitexin, with several phenolics newly reported for roots.
View Article and Find Full Text PDFHost-Pathogen Interaction Activated Biosynthesis of Natural Products.
J Nat Prod
August 2025
Faculty of Science and Technology, Keio University, Yokohama 223-8522, Japan.
The way immune cells attack pathogenic microorganisms might trigger pathogens to produce compounds that promote their survival. Based on this idea, we constructed a coculture system of pathogenic fungi and immune cells and isolated fumigatinolactone () as a new natural product by coculture of IFM 60237 with RAW264 mouse macrophage-like cells. Fumigatinolactone () was produced via a nonenzymatic coupling reaction between fumigatin () and a new type of intermediate fumarylazlactone ().
View Article and Find Full Text PDFA Mononitrosyl Diiron(II) Compound Catalyzes the Reduction of Nitrite to Nitric Oxide.
Inorg Chem
September 2025
School of Chemical Sciences, Indian Association for the Cultivation of Science, 2A & 2B Raja S. C. Mullick Road, Kolkata, West Bengal 700032, India.
A diiron(II) compound, [Fe(HPTP)(NCS)(DMF)] (), mediated the direct reduction of nitrite (NO) to nitric oxide (NO) in 100% yield and allowed the generation of a mononitrosyl diiron(II) compound, [Fe(HPTP)(NCS)(NO)] (). Compound is a rare [Fe{FeNO}] species, which featured Fe-N and N-O distances of 1.768(4) Å and 1.
View Article and Find Full Text PDF