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ESC Guidelines provide best practice, evidence-based recommendations for diagnosing and treating patients with cardiovascular diseases. It is not always possible for best practices to be followed, however, particularly in low-resource settings. To address this issue, a set of guideline-related documents were created to identify key priorities for users in these settings. The documents highlight the related recommendations and describe key strategies for clinicians to approach implementation of these recommendations or discuss alternatives which are in line with the intention of the recommendations, if not having all of the same advantages. The suggestions cannot be used as exact substitutes for the original recommendations in the guidelines, which have not been altered and continue to reflect best practice. This document on key priorities for low-resource settings was developed by the task force Chairs and other members of the task force who produced the 2023 ESC Guidelines for the management of acute coronary syndromes, which are freely available on the ESC website (https://www.escardio.org/Guidelines). This document also underwent external review including international experts from within and beyond Europe and ESC partner organizations, including the Interamerican Society of Cardiology (IASC), the Pan-African Society of Cardiology (PASCAR), the Asian Pacific Society of Cardiology (APSC), and the ASEAN Federation of Cardiology (AFC).
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http://dx.doi.org/10.1093/ehjqcco/qcae107 | DOI Listing |
PLoS Negl Trop Dis
September 2025
Department of Tropical Medicine and Infectious Disease, Tulane University, New Orleans, Louisiana, United States of America.
Introduction: Neglected tropical diseases (NTDs) are a priority in the public health agenda for Côte d'Ivoire, with persons living with disabilities due to NTDs (PD-NTDs) experiencing many challenges in their daily lives. Current policies do not sufficiently support PD-NTDs, thereby highlighting the need to identify opportunities for policy improvement.
Methods: This study was carried out in two phases: first to identify the current needs (formative phase) and then to develop a pilot strategy (implementation phase).
ACS Appl Mater Interfaces
September 2025
College of Metrology Measurement and Instrument, China Jiliang University, Hangzhou 310018, China.
During the long course of evolution, fish have developed complex skin structures to adapt to the dynamic aquatic environment. These skin features not only reflect optimal adaptation to the aquatic environment but also play a key role in effectively reducing fluid drag and improving swimming efficiency, to reveal the intrinsic connection between the complex skin structure of fish and drag reduction performance and to provide new design ideas for the drag reduction surface of underwater vehicles. Based on the different drag reduction characteristics of fish skin structures, this paper divides existing biomimetic drag reduction technologies into three categories: riblet drag reduction, flexible drag reduction, and composite drag reduction.
View Article and Find Full Text PDFAdv Sci (Weinh)
September 2025
China-New Zealand Joint Laboratory on Biomedicine and Health, State Key Laboratory of Immune Response and Immunotherapy, Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, GIBH-HKU Guangdong-Hong Kong Stem Cell and Regenerative Medicine Research Centre, GIBH-CUHK Joint Resea
TP53 mutations are highly associated with hepatocellular carcinoma (HCC), a common and deadly cancer. However, few primary drivers in the progression of HCC with mutant TP53 have been identified. To uncover tumor suppressors in human HCC, a genome-wide CRISPR/Cas9-based screening of primary human hepatocytes with MYC and TP53 overexpression (MT-PHHs) is performed in xenografts.
View Article and Find Full Text PDFBMJ Public Health
August 2025
Department of Health Services, Policy, Planning, Management and Economics, School of Public Health, University for Development Studies, Tamale, Ghana.
Introduction: Obstetric fistula is a form of maternal morbidity that can lead to prolonged disability and poor quality of life. This study explored the healthcare needs and treatment-seeking patterns of women living with obstetric fistula in the Tamale Metropolis.
Methods: A qualitative phenomenology design was used.
Cureus
August 2025
Department of Radiation Oncology, University of North Carolina, Chapel Hill, USA.
Background: Integrating a practice-based curriculum to cover essential aspects of patient safety and quality improvement (PSQI) in the outpatient setting can improve resident understanding and engagement in future projects within a radiation oncology residency program.
Objectives: To develop and pilot a workshop-based PSQI curriculum to lead residents through a simulated departmental quality improvement project and enhance understanding regarding tools and metrics used within a PSQI framework.
Methods: This pilot project was completed in the 2023-2024 academic year, with 13 residents in one radiation oncology program.