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http://dx.doi.org/10.1097/XCS.0000000000001394 | DOI Listing |
Trends Biotechnol
September 2025
School of Molecular Biosciences, University of Glasgow, Glasgow G12 8QQ, UK. Electronic address:
A key step in the precision fermentation of casein proteins is correct phosphorylation to generate one or more short linear sequence motifs (SLiMs) containing three or more phosphorylated seryl residues. The work of Balasubramanian et al. takes us a step closer to that goal by showing that two bacterial phosphokinases are promising alternatives to the mammalian Golgi phosphokinases and casein kinase-II.
View Article and Find Full Text PDFClin Pharmacol Ther
September 2025
Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands.
Clinical trials often face recruitment challenges. From the participant's perspective, barriers such as time commitment, travel to sites, and logistical burden, like arranging care duties or time off work, can deter enrolment. Decentralized clinical trials (DCTs) aim to address these by shifting activities closer to participants' homes and using online methods for recruitment and consent.
View Article and Find Full Text PDFCurr Oncol
August 2025
Faculty of Medicine, Memorial University of Newfoundland, St. John's, NL A1B 3V6, Canada.
(1) Background: Bispecific antibodies (BsAbs) for the treatment of relapsed/refractory diffuse large B-cell lymphoma (R/R DLBCL) can be delivered in ambulatory healthcare settings; however, the safe and effective management of potential side effects, such as cytokine release syndrome (CRS), requires protocolized monitoring and management. (2) Methods: An Expert Working Group (EWG) of nine hematologists from across Canada, with experience in leading BsAb program implementation, combined a review of published literature, a comparison of national/provincial/regional guidance documents and protocols, and their professional experiences to produce an informed framework for BsAb program implementation in various healthcare settings. (3) Results: The EWG supports and recommends the progression of BsAb provision from predominantly inpatient hospital settings to community/ambulatory care settings closer to the patient's home.
View Article and Find Full Text PDFJCI Insight
August 2025
Université de Lorraine, CNRS, IMoPA, UMR 7365, F-54000 Nancy, France.
Ehlers-Danlos syndromes (EDS) comprise a genetically and clinically heterogenous group of rare diseases that cause severe, often fatal, damage to connective tissue. The molecular basis of EDS implicates defects in extracellular matrix components, including various fibrillar collagens and glycosaminoglycans (GAGs). However, the precise pathogenic mechanisms behind EDS remain elusive.
View Article and Find Full Text PDFLangmuir
September 2025
Department of Chemistry, Pontifical Catholic University of Rio de Janeiro (PUC-Rio), Rio de Janeiro 22451-900, Brazil.
Most studies on surfactant adsorption onto minerals have primarily relied on simplified isotherm models, which fail to account for the anomalous behavior observed after micelle formation. In this work, we introduce a novel three-step adsorption model that builds upon the classical two-step theory by incorporating a micelle-triggered desorption mechanism. This discontinuous and implicit step, activated at the critical micelle concentration, accounts for surface aggregate desorption induced by micelles, a phenomenon previously unaddressed in adsorption isotherms.
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