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This paper analyzes for the first time how the Beckmann distribution can be used to characterize the random variable that represents the envelope of the effective channel gain experienced by the -th user equipment (UE) of a user-centric (UC) cell-free (CF) system in a scenario with noisy channel state information (CSI) estimation and line of sight (LoS). Additionally, it is shown how the Beckmann probability density function (PDF) can be used to derive the PDF and the cumulative density function (CDF) of the instantaneous signal-to-interference-plus-noise ratio (SINR) of the UC CF -th UE, followed by applications in the ergodic capacity (EC) and outage probability (OP) expression derivations. It is shown that, regardless of the type of distribution considered for the channel gain between each access point (AP) and UE links, the effective gain presents a Beckmann distribution.
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http://dx.doi.org/10.3390/e27030223 | DOI Listing |
Cell Rep
September 2025
Department of Neurology, University of California, Los Angeles, David Geffen School of Medicine, Los Angeles, CA 90095, USA; Department of Neurobiology, University of California, Los Angeles, Los Angeles, CA 90095, USA; Eli and Edythe Broad Center for Regenerative Medicine and Stem Cell Research, Un
Neurodevelopmental disorders often impair multiple cognitive domains. For instance, a genetic epilepsy syndrome might cause seizures due to cortical hyperexcitability and present with memory impairments arising from hippocampal dysfunction. This study examines how a single disorder differentially affects distinct brain regions using induced pluripotent stem cell (iPSC)-derived cortical- and hippocampal-ganglionic eminence assembloids to model developmental and epileptic encephalopathy 13, a condition arising from gain-of-function mutations in the SCN8A gene encoding the sodium channel Nav1.
View Article and Find Full Text PDFACS Omega
September 2025
Neuroscience and Ageing Biology Division, CSIR- Central Drug Research Institute (CDRI), Lucknow 226031, India.
The TRPA1 channel has recently emerged as a critical target for pain relief since its antagonists target the beginning of the pain transduction pathway and, thus, are devoid of side effects such as sedation, dizziness, somnolence, or cognitive impairment. Despite this clinical significance, currently, no TRPA1 inhibitors suitable for therapeutic usage exist to target these channels. Since ancient times, natural products have been known to be a rich source of new drugs, useful therapeutic agents, as well as pharmacological tools.
View Article and Find Full Text PDFThe complement component C3, factor B (FB) and factor D (FD) belong to the alternative complement pathway and have been identified in urine samples from nephrotic mice. However, it is not yet known whether these factors are involved in mediating sodium retention in nephrotic syndrome (NS). Here we used a genetic mouse model of NS based on an inducible podocin deletion ( ).
View Article and Find Full Text PDFIEEE Trans Neural Syst Rehabil Eng
September 2025
Sleep monitoring is essential for assessing sleep quality and understanding its broader implications for overall health. Although electroencephalography (EEG) remains the gold standard for sleep analysis, multichannel techniques are often cumbersome and impractical for real-world application. As a more feasible alternative, single-channel EEG offers greater practicality but still faces several persistent challenges, including reduced spatial resolution, feature instability, and limited clinical interpretability.
View Article and Find Full Text PDFFASEB J
September 2025
Department of Pathology, University of Maryland School of Medicine, Baltimore, Maryland, USA.
P/Q-type (Ca2.1) Ca channels regulate the release of neurotransmitter at central synapses. Missense and nonsense mutations in CACNA1A, the gene that encodes the principal α subunit of the Ca2.
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