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Background: Referral to advanced heart failure care (AHFC) is advocated to ensure favorable outcomes, and it has been shown to improve prognosis and quality of life in patients at advanced stages of disease. Nevertheless, it may occur later than desired; the rate of eligible patients referred in a timely manner is unknown. We sought to describe the current state of referral for AHFC, highlight potential factors leading to delayed referral and discuss strategies to increase access to AHFC.
Methods And Results: We performed electronic searches on Pubmed, EMBASE, Web of Science, and The Cochrane Library to identify studies describing referral patterns to advanced heart failure, patient and provider characteristics associated with increased or decreased referral, settings of care, and associated clinical outcomes. We then discuss possible reasons for referral delay, as well as potential avenues for research and directed intervention to reduce delay and improve patients' outcomes.
Conclusion: A referral delay currently exists for AHFC, driven by multiple factors, among them providers' misconceptions about the benefits of AHFC and the appropriate timing of referral, a lack of specialized providers, insufficient and unequal access to care across demographics, and patients' lack of awareness. Efforts to reduce these and other root causes are needed to improve referral rates and optimize outcomes for patients with HF.
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http://dx.doi.org/10.1016/j.cardfail.2025.03.015 | DOI Listing |
Dan Med J
August 2025
Research Unit for General Practice, Department of Public Health, University of Southern Denmark.
Introduction: In various countries, an increasing proportion of general practitioner (GP) referrals is returned by hospitals. We aimed to uncover the causes and consequences of referral returns from the perspective of GP liaisons.
Methods: Individual interviews with 20 GP liaison officers from various departments in Southern Denmark, serving 1.
Turk J Pediatr
September 2025
Division of Developmental Pediatrics, Department of Pediatrics, Faculty of Medicine, Hacettepe University, Ankara, Türkiye.
Background: Autism spectrum disorder (ASD) is more frequently diagnosed in boys than in girls, possibly due to gender-based differences in symptom presentation or referral patterns. This study investigates gender-related variations in symptom severity and clinical presentation among preschool children referred for suspected ASD.
Methods: This study included 125 children (boys: n=103; girls: n=22) aged 2-5 years suspected of having ASD.
Turk J Pediatr
September 2025
Department of Pediatric Hematology, Faculty of Medicine, Dokuz Eylül University, İzmir, Türkiye.
Backround: Leukemia is the most common childhood malignancy and often presents with nonspecific symptoms, which may lead to delays in diagnosis. Early recognition of clinical signs and laboratory abnormalities is essential to ensure timely referral and improve outcomes. This study assesses the clinical and laboratory characteristics of pediatric patients with acute and relapsed leukemia, points out key considerations during diagnosis, and investigates potential factors contributing to delayed diagnosis.
View Article and Find Full Text PDFRheumatol Int
September 2025
Division of Rheumatology and Immunology, Department of PMR, , Sakarya University School of Medicine, Sakarya, Turkey.
To identify clinical and demographic predictors associated with the timing of transition from psoriasis (PsO) to psoriatic arthritis (PsA), and to compare the characteristics of patients with concurrent PsO-PsA onset versus those with prolonged transition. A multi-center, observational study was conducted using data from the Turkish League Against Rheumatism (TLAR) network including PsA patients fulfilling CASPAR criteria. Patients were categorized into two groups: Group 1 (concurrent PsO and PsA onset within ± 1 year) and Group 2 (prolonged transition to PsA, > 1 year after PsO).
View Article and Find Full Text PDFAllergol Immunopathol (Madr)
September 2025
Department of Allergy and Immunology, University of Health Sciences, Süreyyapaşa Training and Research Hospital, Istanbul, Turkey.
Background: Antituberculosis drugs can cause hypersensitivity reactions that interrupt treatment and increase morbidity. Early identification and management are essential to prevent complications and drug resistance.
Objective: To evaluate the clinical characteristics, risk factors, and outcomes of antituberculosis drug-induced hypersensitivity reactions over a 10-year period in a tertiary referral center.