Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Background: The calculation of conventional extracellular volume fraction (ECV) requires blood hematocrit (Hct) measurement. Based on the relationship between Hct and blood T1 relaxivity for cardiac magnetic resonance (CMR), a synthetic ECV could be estimated without a blood sampling. The aim of this study was to evaluate the correlation and agreement in the quantification of synthetic ECV and laboratory ECV from conventional Hct measurements.
Methods: Electronic database searches of PubMed, Web of Science Core Collection, Cochrane advanced search, and EMBASE were performed. The authors employed a meta-analysis using the generic inverse variance method with a random-effects model to estimate the summary correlation coefficient and mean absolute difference between synthetic and laboratory ECV.
Results: Of 38 papers, 10 studies comprising 4492 patients were identified. Overall, there was an excellent correlation between synthetic ECV and laboratory ECV (0.95 [95% confidence interval (CI): 0.92 to 0.97]) at 1.5T CMR and (0.91 [95% CI: 0.86 to 0.94]) at 3.0T CMR. The pooled mean difference between synthetic ECV and laboratory ECV was 0.61% (95% CI: 0.23 to 0.98%, I = 0%, p for heterogeneity = 0.67) at 1.5T CMR and 0.24% (95% CI: -0.13 to 0.61%, I = 19%, p for heterogeneity = 0.25) at 3.0T CMR.
Conclusion: This study is the first comprehensive systematic review and meta-analysis of synthetic ECV evaluation at CMR. Synthetic ECV demonstrated an excellent correlation with laboratory ECV, with a mean difference of less than 1%, and offers noninvasive and instantaneous quantification of the myocardial extracellular space without the need for blood sampling.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12138551 | PMC |
| http://dx.doi.org/10.1016/j.jocmr.2025.101889 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Effect of age and sex on cardiac magnetic resonance native T1 mapping and synthetic extracellular volume.
Int J Cardiol
August 2025
Department of Cardiology, Inselspital, Bern University Hospital, University of Bern, Bern, Switzerland; Department of Nuclear Medicine, University Hospital Zurich, Zurich, Switzerland; Center for Molecular Cardiology, University of Zurich, Schlieren, Switzerland.
Background: Cardiac magnetic resonance (CMR) using native T1 mapping and extracellular volume (ECV) fraction is the gold standard for noninvasive detection of diffuse myocardial fibrosis. Previous studies indicate that women tend to have higher native T1 and ECV values than men, but how these parameters evolve with cardiac aging remains unclear.
Methods And Results: Relations between age, sex, and native T1 and synthetic ECV were assessed in 306 individuals (mean age 45 ± 18 years; 47.
Optimizing synthetic hematocrit for cardiac MRI: a multivariable model calibrated with standardized venous sampling.
Int J Cardiovasc Imaging
August 2025
Department of Radiology, Kütahya Health Sciences University, Kütahya, TR-43020, Türkiye, Turkey.
Cardiac magnetic resonance (CMR) is a key modality for non-invasive extracellular volume (ECV) quantification, typically requiring venous hematocrit (Hct). However, fluctuations in Hct can affect accuracy. This study aimed to develop a synthetic Hct model integrating age, sex, and pre- and post-contrast blood pool T1 values, calibrated against an optimized venous Hct reference.
View Article and Find Full Text PDFSynthetic hematocrit-based extracellular volume quantification from photon-counting CT: Validation against MRI and systematic bias correction.
Eur J Radiol
October 2025
Department of Radiology and Radiological Science, Medical University of South Carolina, Charleston, USA; Department of Diagnostic and Interventional Radiology, University Medical Center of the Johannes Gutenberg-University, Mainz, Germany; German Centre for Cardiovascular Research, Partner site Rhin
Purpose: To assess the feasibility and accuracy of synthetic hematocrit (Hct)-based myocardial extracellular volume (ECV) quantification using photon-counting detector (PCD)-CT late enhancement (LE) imaging, with cardiac MRI as the reference standard.
Methods: In this post-hoc analysis of a prospective study, patients underwent same-day cardiac MRI and PCD-CT LE imaging. MRI-based ECV (ECV) was computed using T1 mapping sequences before and after contrast administration.
Establishment of a synthetic ECV model and its prognostic value in diabetes patients with acute myocardial infarction.
Front Endocrinol (Lausanne)
July 2025
Department of Cardiology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, China.
Background: Extracellular volume (ECV) is an important marker of myocardial fibrosis. However, the prognostic role of ECV in diabetes patients is unknown. In addition, synthetic ECV without blood sampling has not been reported in diabetes cohorts.
View Article and Find Full Text PDFSynthetic extracellular volume fraction as an imaging biomarker of the myocardial interstitium without blood sampling: a systematic review and meta-analysis.
J Cardiovasc Magn Reson
June 2025
Department of Diagnostic Radiology, Yokohama City University Graduate School of Medicine, Yokohama, Kanagawa, Japan.
Background: The calculation of conventional extracellular volume fraction (ECV) requires blood hematocrit (Hct) measurement. Based on the relationship between Hct and blood T1 relaxivity for cardiac magnetic resonance (CMR), a synthetic ECV could be estimated without a blood sampling. The aim of this study was to evaluate the correlation and agreement in the quantification of synthetic ECV and laboratory ECV from conventional Hct measurements.
View Article and Find Full Text PDF