AID/APOBEC: an expanding repertoire of targets and functions.

Trends Biochem Sci

Department of Molecular and Systems Biology, Institute of Bioorganic Chemistry, Polish Academy of Sciences, Noskowskiego 12/14, 61-704, Poznan, Poland. Electronic address:

Published: August 2025


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Article Abstract

Deaminases belonging to the AID/APOBEC family are known as ssDNA and mRNA mutators involved in innate/adaptive immunity, mRNA editing, genome stabilization by restricting retrotransposons, and carcinogenesis. Recent studies suggest that the repertoire of AID/APOBEC targets is more diverse than previously thought and imply a broader biological impact of these proteins.

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http://dx.doi.org/10.1016/j.tibs.2025.02.006DOI Listing

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