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Oscillatory behavior is ubiquitous in many natural and engineered systems, often emerging through self-regulating mechanisms. In this paper, we address the challenge of stabilizing a desired oscillatory pattern in a networked system where neither the internal dynamics nor the interconnections can be changed. To achieve this, we propose two distinct control strategies. The first requires the full knowledge of the system generating the desired oscillatory pattern, while the second only needs local error information. In addition, the controllers are implemented as co-evolutionary, or adaptive, rules of some edges in an extended plant-controller network. We validate our approach in several insightful scenarios, including synchronization and systems with time-varying network structures.
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http://dx.doi.org/10.1063/5.0230879 | DOI Listing |
Cardiovasc Eng Technol
September 2025
Institute of Computer-assisted Cardiovascular Medicine, Deutsches Herzzentrum der Charité (DHZC), Berlin, Germany.
In the field of cardiovascular device development, new devices such as heart valves, stents or pressure probes for long term heart failure monitoring are subject to animal trials to evaluate their safety and efficacy. For such applications, swine and sheep are the animal models of choice owed to their similarities to humans with regards to heart size, weight and ventricular kinetics. However, clinical aspects regarding the choice of animal model revolve mainly around anatomical similarities as well as the ability to induce the desired pathology.
View Article and Find Full Text PDFInt J Pharm
September 2025
Laboratory of Pharmaceutical Process Analytical Technology (LPPAT), Ghent University, Ottergemsesteenweg 460, 9000 Ghent, Belgium. Electronic address:
An increasing number of published studies have highlighted the benefits of continuous manufacturing technologies for producing topical pharmaceuticals. In light of this, the present study aimed to investigate the development of a topical pharmaceutical hydrogel containing clobetasol propionate encapsulated liposomes using a continuous manufacturing system. By applying the Quality-by-Design (QbD) concept, the desired quality target profile of clobetasol propionate-loaded liposomes (CPLs) for topical use was initially determined, in which the drug entrapment concentration, encapsulation efficiency, particle size, and polydispersity index (PDI) were investigated as critical quality attributes (CQAs).
View Article and Find Full Text PDFDev Biol
October 2025
Department of Biology, William and Mary, Williamsburg, VA, USA.
The publication of two landmark papers in the year 2000 demonstrated that scientists could rationally engineer genetic circuits to perform desired biological processes commonly found in nature. Elowitz and Leibler constructed a repressilator based on a negative feedback loop that showed oscillatory behavior, and the Collins lab engineered a toggle switch that was able to switch between and maintain stable states in response to external stimuli. Although built upon a long history of conceptual and technical advances in the field, both studies were nevertheless instrumental in transforming the way investigators studied complex biological processes.
View Article and Find Full Text PDFRespir Med Case Rep
May 2025
Department of Pediatrics, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo, 160-8582, Japan.
To prevent the worsening of bronchopulmonary disease (BPD), early extubation is desirable. However, in extremely preterm infants, BPD tends to become severe, making early extubation difficult and leading to prolonged intubation. Even if the intubation period is prolonged, feasible respiratory strategies for extubation in extremely preterm infants during the chronic phase of severe BPD are necessary.
View Article and Find Full Text PDFBrain Sci
April 2025
Mental Health Service, VA San Diego Healthcare System, La Jolla, CA 92161, USA.
Brain stimulation therapies may be used to correct motor, social, emotional, and cognitive consequences of traumatic brain injury (TBI). Neuromodulation applied with anatomical specificity can ameliorate desired symptoms while leaving functional circuits intact. Before applying precision medicine approaches, preclinical animal studies are needed to explore potential neurophysiological signatures that could be modulated with neurostimulation.
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