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Background: Unplanned readmissions are associated with increased mortality among older patients. This study investigated the effects of changes in physical function and frailty on unplanned readmissions in middle-aged and older patients after discharge.
Methods: This longitudinal study recruited participants through convenience sampling from the general wards of a medical center in northern Taiwan. They were aged 50 years or older and identified as being at high risk for readmission or mortality following discharge. Baseline data were collected through interviews conducted the day before discharged, while follow-up data were obtained through interviews at 1, 2, and 3 months post-discharge. Generalized estimating equation (GEE) was used for statistical analysis, incorporating all tracked variables, including physical function and frailty.
Results: A total of 230 participants were recruited, each followed three times after discharge. The unplanned readmission rates at 1, 2, and 3 months post-discharge were 2%, 8%, and 14%, respectively. Participants with poorer physical function (odds ratio [OR] = 1.60 [1.27-2.02]) and more severe frailty symptoms (OR = 3.16 [1.45-6.83]) had significantly higher odds of unplanned readmission. The interaction between the time and frailty indicated a significantly lower likelihood of unplanned readmission over time (OR = 0.73 [0.54-0.98]).
Conclusions: Declining physical function and frailty are key risk factors for unplanned readmission in older patients. Effective strategies to reduce this risk include monitoring physical function and frailty symptoms and providing supportive care services.
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http://dx.doi.org/10.1038/s41598-025-94945-8 | DOI Listing |
Biol Lett
September 2025
Department of Science, Roma Tre University, Rome, Italy.
In the past decades, several authors have investigated the possibility that genome size is correlated with metabolic rates, obtaining conflicting results. The main biological explanation among the supporters of this correlation was related to the nucleotypic effect of the genome size, which, determining the cellular volume and hence the surface area-to-volume ratio, influences cellular metabolism. In the present study, I tested a different hypothesis: genome size, influencing red blood cell (RBC) volume, is correlated with capillary density and diameter.
View Article and Find Full Text PDFDan Med J
August 2025
Centre for Health and Rehabilitation, University College Absalon.
Introduction: People with rheumatic and musculoskeletal diseases are advised to do aerobic exercise for symptom relief and to reduce the risk of cardiovascular disease. Continuous exercise at an intensity causing a rate of perceived exertion of 15, on a 6-20-point Borg scale, exemplifies such exercise. Also, the instruction "Now you need to increase your heart rate" is used before aerobic exercise.
View Article and Find Full Text PDFiScience
September 2025
Department of Physical Geography and Ecosystem Science, Lund University, 223 62 Lund, Sweden.
Forest loss, fragmentation, and transformation negatively impact forest biodiversity and ecosystem functionality worldwide. Improving landscape intactness and connectivity through restoration is critical. Determining where to restore remains, however, a challenge.
View Article and Find Full Text PDFInt J Nanomedicine
September 2025
Department of Infectious Diseases, Shandong Provincial Hospital Affiliated to Shandong First Medical University, Jinan, People's Republic of China.
The STING pathway has emerged as a therapeutic target in tumor immunotherapy due to its ability to induce interferon responses, enhance antigen presentation and activate T cells. Despite its therapeutic potential, STING pathway-based tumor immunotherapy has been limited by challenges in poor cellular delivery, rapid degradation of STING agonists, and potential systemic toxicity. Recently, advancements in nanotechnology have tried to overcome these limitations by providing platforms for more accurate and efficient targeted delivery of agonists, more moderate sustained STING pathway activation, and more efficient immune presentation and anti-tumor immune response.
View Article and Find Full Text PDFCrit Care Explor
September 2025
Division of Pulmonary, Allergy, Critical Care, and Sleep, University of Minnesota, Minneapolis, MN.
Mean airway pressure, a monitored variable continuously available on the modern ventilator, is the pressure measured at the airway opening averaged over the time needed to complete the entire respiratory cycle. Mean airway pressure is well recognized to connect three key physiologic processes in mechanical ventilation: physical stretch, cardiovascular dynamics, and pulmonary gas exchange. Although other parameters currently employed in adults to determine "safe" ventilation are undoubtedly valuable for daily practice, all have limitations for continuous monitoring of ventilation hazard.
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