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Article Abstract
Background: Diabetic retinopathy (DR) is a common microvascular complication of diabetes mellitus (DM). A number of studies have investigated if patients with diabetic retinopathy present altered arterial stiffness compared to diabetic individuals without retinopathy.
Objectives: To compare arterial stiffness parameters in participants with diabetic retinopathy (DR) compared to participants with diabetes without retinopathy.
Methods: Medline and Scopus were searched for published articles comparing indices of arterial stiffness in participants with DR and in diabetic participants without retinopathy. Standardized Mean Difference (SMD) with 95% confidence interval (CI) was calculated for the comparisons. The study protocol was registered with PROSPERO with registration ID: CRD42023482577.
Results: The meta-analysis analyzed 3 arterial stiffness parameters brachial ankle PWV, carotid-femoral PWV and augmentation index (AI). 8 studies were included in the analysis of brachial ankle PWV, 4 in the analysis of carotid-femoral PWV and 4 in the analysis of the augmentation index. Brachial ankle PWV, carotid-femoral PWV and augmentation index were found to be increased in participants with DR compared to diabetic participants without DR (SMD = 0.59, 95 %CI = 0.40-0.79, P < 0.00001, I = 89 %, SMD = 0.86, 95 %CI = 0.55-1.18P < 0.00001, I = 91 % and SMD = 0.23, 95 %CI = 0.13-0.32, P < 0.00001, I = 0 %, respectively).
Conclusion: Diabetic participants with DR exhibit increased arterial stiffness compared to diabetic participants without DR.
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| http://dx.doi.org/10.1016/j.diabres.2025.112123 | DOI Listing |
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