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Arctic coastal biodiversity faces increasing threats from anthropogenic activities and climate change. However, the effects on biodiversity are still poorly understood, hindering actions aimed at mitigating the impacts at a pan-Arctic scale. We present the results of a horizon scan that provides a road map to address knowledge gaps on the influence of anthropogenic activities, from increased shipping and harvesting to consequences of climate change including increasing temperatures, cryosphere loss, and freshwater runoff. Predictions on ecological change, species range expansions, and anthropogenic impacts on Arctic coasts are hampered by the lack of biodiversity data and scarcity of biological long-term monitoring programs. Filling these knowledge gaps will require coordinated international efforts and standardized experiments across the diverse ecosystems characterizing the Arctic.
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http://dx.doi.org/10.1016/j.tree.2025.02.008 | DOI Listing |
Neurol Neuroimmunol Neuroinflamm
November 2025
Department of Neurology, Johns Hopkins University School of Medicine, Baltimore, MD.
Background And Objectives: Optical coherence tomography (OCT) allows evaluation of inter-eye differences (IEDs) in macular ganglion cell-inner plexiform layer (GCIPL) and peripapillary retinal nerve fiber layer (pRNFL) thicknesses to identify unilateral optic nerve involvement (UONI). UONI supports dissemination in space (DIS) as part of the 2024 revised McDonald diagnostic criteria for multiple sclerosis (MS). The OSCAR-IB quality control (QC) criteria identify suboptimal-quality OCT scans, which could potentially result in false-positive or false-negative UONI identification.
View Article and Find Full Text PDFAlzheimers Dement
July 2025
Institute of Neuroscience and Physiology, the Sahlgrenska Academy at the University of Gothenburg, Gothenburg, Sweden.
Introduction: Positron emission tomography (PET) imaging with ligands for synaptic vesicle glycoprotein 2A (SV2A) has emerged as a promising methodology for measuring synaptic density in Alzheimer's disease (AD). We investigated the relationship between SV2A PET and CSF synaptic protein changes of AD patients.
Method: Twenty-one participants with early AD and seven cognitively normal (CN) individuals underwent [C]UCB-J PET.
JTO Clin Res Rep
September 2025
GO2 for Lung Cancer, Washington, District of Columbia.
Introduction: This study investigated quality of life (QoL) and its role in treatment decision making among patients with anaplastic lymphoma kinase ()+ NSCLC.
Methods: Adult patients with self-reported + NSCLC residing in the United States from the Lung Cancer Registry from GO2 for Lung Cancer were included. Measures included a core patient survey derived from Quality of Life Questionnaire - Core 30 items (QLQ-C30) and QLQ - lung cancer module 29 items domains and an NSCLC module (ALK module).
Nat Ecol Evol
August 2025
Securing Antarctica's Environmental Future, School of Biology and Environmental Science, Queensland University of Technology, Brisbane, Queensland, Australia.
Antarctica, long considered an environmental sanctuary, now confronts accelerating, complex and inter-related conservation challenges. The vast size and remote location of the continent introduce substantial uncertainty in understanding and predicting these threats. Here, using strategic foresight techniques, we synthesized insights from a global horizon scan with 131 experts from 42 countries.
View Article and Find Full Text PDFInt J Mol Sci
July 2025
Center for Medical Physics and Biomedical Engineering, Medical University of Vienna, Waehringer Guertel 18-20, 1090 Vienna, Austria.
Cardiac fibrosis following myocardial infarction plays a critical role in the formation of scar tissue and contributes to ventricular arrhythmias, including ventricular tachycardia and sudden cardiac death. Current clinical diagnostics use electrical and structural markers, but lack precision due to low spatial resolution and absence of molecular information. In this paper, we employed line scan Raman microspectroscopy to classify sheep myocardial tissue into muscle, necrotic, granulated, and fibrotic tissue types, using collagen as a molecular biomarker.
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