98%
921
2 minutes
20
Aims: To explore the potent anti-inflammatory and anti-tuberculosis potential of novel trimetallic Au-Pt-Cu nanofluids.
Materials & Methods: We employed BSA assay for anti-inflammatory assessment and tested anti-tuberculosis activity against H37Rv. Advanced molecular docking, dynamics, and DFT analyses were conducted to reveal interaction mechanisms and electronic properties.
Results: The nanofluids demonstrated impressive IC values (15.88 ± 0.09 μM and 0.54 ± 0.02 μg/ml), with strong binding affinities and stable interactions confirmed via molecular simulations. Favorable ADMET profiling highlights their promise as innovative therapeutic agents.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11938965 | PMC |
http://dx.doi.org/10.1080/17568919.2025.2478818 | DOI Listing |
Int J Plant Anim Environ Sci
August 2025
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Neurological disorders, such as Alzheimer's disease, Parkinson's disease, epilepsy, spinal cord injuries, and traumatic brain injuries, represent substantial global health challenges due to their chronic and often progressive nature. While allopathic medicine offers a range of pharmacological interventions aimed at managing symptoms and mitigating disease progression, it is accompanied by limitations, including adverse side effects, the development of drug resistance, and incomplete efficacy. In parallel, phytochemicals-bioactive compounds derived from plants-are receiving increased attention for their potential neuroprotective, antioxidant, and anti-inflammatory properties.
View Article and Find Full Text PDFFood Sci Nutr
September 2025
Panvascular Diseases Research Center, Quzhou People's Hospital The Quzhou Affiliated Hospital of Wenzhou Medical University Quzhou China.
Date fruit ( L.) is a highly nutritious and therapeutic food with substantial potential to improve human health. This review emphasizes the nutritional and therapeutic traits of date fruit, focusing on its role as a functional food and dietary supplement.
View Article and Find Full Text PDFBiomaterials
September 2025
Key Laboratory of Biopharmaceutical Preparation and Delivery, Institute of Process Engineering, Chinese Academy of Sciences, Beijing, 100190, PR China; University of Chinese Academy of Sciences, Beijing, 100049, PR China. Electronic address:
The stimulator of interferon genes (STING) pathway represents a promising target in cancer immunotherapy. However, the clinical translation of cyclic dinucleotide (CDN)-based STING agonists remains hindered by insufficient formation of functional CDN-STING complexes. This critical bottleneck arises from two interdependent barriers: inefficient cytosolic CDN delivery and tumor-specific STING silencing via DNA methyltransferase-mediated promoter hypermethylation.
View Article and Find Full Text PDFACS Nano
September 2025
Department of Emergency and Critical Care Medicine, The Fourth Affiliated Hospital of Soochow University, Suzhou 215124, China.
Acute lung injury (ALI) is characterized by the excessive accumulation of reactive oxygen species (ROS), which triggers a severe inflammatory cascade and the destruction of the alveolar-capillary barrier, leading to respiratory failure and life-threatening outcomes. Considering the limitations and adverse effects associated with current therapeutic interventions, developing effective and safe strategies that target the complex pathophysiological mechanisms of ALI is crucial for improving patient outcomes. Herein, we developed an inhalable, multifunctional nanotherapeutic (MSCNVs@CAT) by encapsulating catalase (CAT) in mesenchymal-stem-cell-derived nanovesicles (MSCNVs).
View Article and Find Full Text PDFOpen Life Sci
August 2025
Department of Zoology, College of Science, King Saud University, P.O. Box 2455, Riyadh, 11451, Saudi Arabia.
The present study aimed to evaluate the therapeutic potential of with silver nanoparticles (AgNPs) and chloroquine (CQ) 10 mg/kg in treating lung inflammation caused by infection in a mouse model. Fifty female C57BL/6 mice were divided into five groups: control, leaf extract (IOLE) AgNPs treated, infected, infected and IOLE AgNPs treated, infected and CQ 10 mg/kg treated. Lung histopathology was assessed using microscopic analysis and immunohistochemistry investigation for TNF-α and IL-6.
View Article and Find Full Text PDF