Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Introduction: Sessile serrated lesions (SSLs) are a class of colon polyps challenging to detect through current screening methods but highly associated with colon cancer. To improve detection, we sought a biomarker sensitive for SSLs. Recent endoscopic and histopathologic studies suggest that SSLs are associated with alterations in intestinal mucin expression, but the frequency with which this occurs is not known.
Methods: We performed a meta-analysis of available pathologic studies comparing mucin expression on SSLs to normal colonic mucosa, tubular adenomas, villous adenomas, traditional serrated adenomas (TSAs), and hyperplastic polyps (HPs). We searched Medline, Pubmed, and Embase and found 440 publications in this topic, and 18 total studies met inclusion.
Results: We found that MUC5AC expression was more common in SSLs compared to normal colonic mucosa (OR = 82.9, P < 0.01), tubular adenoma (OR = 11, P < 0.01), and TSAs (OR = 3.6, P = 0.04). We found no difference in MUC5AC expression between SSLs versus HPs (OR = 2.1, P = 0.09) and no difference in MUC5AC expression between left colon and right colon HPs, with an OR = 1.8, P = 0.23.
Discussion: We found that MUC5AC expression was found commonly on villous adenoma, SSLs, and TSAs while the frequency on colon cancers declined. MUC5AC is also upregulated in inflammatory bowel disease and in response to intestinal infections. MUC5AC expression highlights the potential of mucins as useful biomarkers, though not specific to SSLs. Further research into the clinical utility of MUC5AC as a pathologic or fecal biomarker could enhance SSL detection.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101924 | PMC |
| http://dx.doi.org/10.14309/ctg.0000000000000831 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Senkyunolide I alleviates allergic rhinitis by inhibiting JAK1/3-STAT3/6 and JNK signalings.
Int Immunopharmacol
September 2025
Department of Otolaryngology, Hospital of Chengdu University of Traditional Chinese Medicine, Chengdu University of Traditional Chinese Medicine, Chengdu 610075, China. Electronic address:
Background: Allergic rhinitis (AR) is a common allergic disease with a high incidence rate. Senkyunolide I (SEI), a bioactive ingredient isolated from Ligusticum sinense 'Chuanxiong', exhibits known analgesic and anti-inflammatory effects, yet its anti-AR potential remains unexplored. Here, we aim to investigate the therapeutic efficacy and molecular mechanisms of SEI against AR.
View Article and Find Full Text PDFInhibitory effects of Raphanus sativus root extracts on MUC5AC gene expression in human airway epithelial cells.
NPJ Sci Food
August 2025
Graduate Institute of Biotechnology, National Chung Hsing University, Taichung, Taiwan.
The root of Raphanus sativus (radish) is recognized for its bioactive compounds with anti-inflammatory, anti-tumor, and muscle spasm-inhibiting properties. This study explores the effects of different radish extracts on the overexpression of the MUC5AC gene, induced by phorbol 12-myristate 13-acetate (PMA), in human airway epithelial cells (NCI-H292). Our results showed that both methanol and ethyl acetate extracts significantly reduced PMA-induced mucus secretion, as confirmed by PAS staining.
View Article and Find Full Text PDFAAV-mediated MUC5AC siRNA delivery to prevent mucociliary dysfunction in asthma.
Gene Ther
August 2025
Fischell Department of Bioengineering, University of Maryland, College Park, MD, USA.
The main structural components of mucus produced in the lung are mucin 5B (MUC5B) and mucin 5AC (MUC5AC) where a relatively higher expression of MUC5B is typical in health. In the lungs of individuals with asthma, there is a shift from MUC5B to MUC5AC as the predominantly secreted mucin which has been shown to impair mucociliary clearance (MCC) and increase airway mucus plug formation. Given its role in asthmatic lung disease, MUC5AC represents a potential therapeutic target where a gene delivery approach could be leveraged to modulate its expression.
View Article and Find Full Text PDFTaxifolin Regulates the Gene Expression of MUC5AC Mucin via Affecting IκBα/NF-κB p65 Signaling in Human Airway Epithelial Cells.
Biomol Ther (Seoul)
September 2025
Department of Pharmacology and Department of Medical Science, College of Medicine, Chungnam National University, Daejeon 35015, Republic of Korea.
In this study, we explored the effects of taxifolin, a flavonoid compound, on the expression of the MUC5AC mucin gene in airway epithelial cells. Human pulmonary epithelial NCI-H292 cells were pretreated with taxifolin for 30 min prior to stimulation with phorbol 12-myristate 13-acetate (PMA) for 24 h. We also investigated the influence of taxifolin on the PMA-induced activation of the NF-κB signaling pathway.
View Article and Find Full Text PDFDifferentiating Neoplastic From Non-neoplastic Gallbladder Lesions Using MUC1 and MUC5AC: An Immunohistochemical Analysis.
Cureus
July 2025
Department of Pathology, Hind Institute of Medical Sciences, Sitapur, IND.
Background: Gallbladder lesions range from benign inflammatory conditions to malignancies, often progressing through pre-neoplastic stages. Accurate histopathological differentiation, particularly in early stages, remains challenging. Mucin proteins MUC1 and MUC5AC have emerged as potential immunohistochemical (IHC) markers for distinguishing neoplastic from non-neoplastic gallbladder pathology.
View Article and Find Full Text PDF