Category Ranking
98%
Total Visits
921
Avg Visit Duration
2 minutes
Citations
20
Article Abstract
Psychedelics, known for their therapeutic potential in psychiatric disorders, interact with the autonomic nervous system in ways that are not well understood. This viewpoint examines the complex relationships between psychedelics and autonomic functions, focusing on sympathetic and parasympathetic modulation. We propose a research framework to elucidate how these interactions influence cardiovascular health and contribute to therapeutic outcomes.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11915027 | PMC |
| http://dx.doi.org/10.1021/acsptsci.5c00005 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Dynamic medial parietal and hippocampal deactivations under DMT relate to sympathetic output and altered sense of time, space, and the self.
Imaging Neurosci (Camb)
April 2025
DMT Research Group, Centre for Psychedelic Research, Department of Brain Sciences, Centre for Psychedelic Research, Imperial College London, London, United Kingdom.
N,N-Dimethyltryptamine (DMT) is a serotonergic psychedelic, known to rapidly induce short-lasting alterations in conscious experience, characterized by a profound and immersive sense of physical transcendence alongside rich and vivid auditory distortions and visual imagery. Multimodal neuroimaging data paired with dynamic analysis techniques offer a valuable approach for identifying unique signatures of brain activity-and linked autonomic physiology-naturally unfolding during the altered state of consciousness induced by DMT. We leveraged simultaneous fMRI and EKG data acquired in 14 healthy volunteers prior to, during, and after intravenous administration of DMT, and, separately, placebo.
View Article and Find Full Text PDFThe psychedelic-peptide paradox: a hormetic hypothesis.
Compr Psychoneuroendocrinol
August 2025
Kinsey Institute, Indiana University and Department of Psychology, University of Virginia, USA.
The purpose of this narrative review is to examine the hypothesis that two neuropeptides, vasopressin (VP) and oxytocin (OT) and their receptors have central roles in the behavioral and physiological consequences of psychedelic interventions. Transient consequences of psychedelics can include anxiety and in some cases sickness responses such as nausea and vomiting, which may involve VP and other components of the hypothalamic-pituitary-adrenal axis. Stressful experiences are often followed by a pulsatile release of OT.
View Article and Find Full Text PDFAbsolute Oral Bioavailability and Bioequivalence of LSD Base and Tartrate in a Double-Blind, Placebo-Controlled, Crossover Study.
Clin Pharmacol Ther
September 2025
Clinical Pharmacology and Toxicology, Department of Biomedicine, University Hospital Basel, Basel, Switzerland.
Lysergic acid diethylamide (LSD) is currently being investigated as a potential treatment for psychiatric and neurological disorders. Different LSD formulations (base or tartrate, oral or intravenous) are being used. Unclear is whether LSD base and tartrate pharmacokinetics are equivalent.
View Article and Find Full Text PDFCyberdelics: Virtual reality hallucinations modulate cognitive-affective processes.
Dialogues Clin Neurosci
December 2025
Humane Technology Lab, Università Cattolica del Sacro Cuore, Milan, Italy.
Introduction: Psychedelics were explored for their potential in the mental health field. However, research was delayed by concerns over short-term side effects and long-term consequences of substance use. Technological advances enabled the development of Hallucinatory Visual Virtual Experiences (HVVEs), namely psychedelic experiences simulations in immersive virtual reality.
View Article and Find Full Text PDFPsilocybin and ketamine affect novel neuropeptides gene expression in the rat hypothalamus.
J Psychopharmacol
May 2025
Department of Pharmacology, Unit II, Maj Institute of Pharmacology, Polish Academy of Sciences, Kraków, Poland.
Objective: Psychedelics are able to trigger highly intense and profound alterations in self-consciousness, perception, affective, and cognitive processes. Indeed, recent studies show that ketamine and psilocybin could be used as fast-acting antidepressants. However, the molecular and neurochemical mechanisms of these psychedelics and their actions at the level of diverse brain structures remains so far unclear.
View Article and Find Full Text PDF