98%
921
2 minutes
20
BackgroundPredicting the course of Parkinson's disease is essential for prompt diagnosis and treatment, which may enhance patient outcomes.ObjectiveThis study presents a novel method for Parkinson's disease prediction using freely accessible resources. The suggested approach starts with band-pass filter data preprocessing and uses Empirical Mode Decomposition (EMD) for feature extraction. Then, for classification, these features are supplied into an Attention-based Efficient Bidirectional Network (ImCfO_Attn_EffBNet) based on Improved Crayfish Optimization. EfficientNet-B7, BiLSTM, and Attention modules are integrated by ImCfO_Attn_EffBNet to effectively gather temporal and geographic data.MethodsAdditionally, we use the Improved Crayfish Optimization (ImCfO) algorithm to maximize convergence rates, optimize the loss function, and find the global best solutions.ResultsImCfO enhances performance by adding a self-adaptation criterion to the traditional crayfish algorithm. The classifier's configurable parameters are adjusted using the ImCfO resultant solution, which raises the prediction accuracy overall.ConclusionBased on a number of assessments, the ImCfO_Attn_EffBNet analyzed the performance and found that the results were as follows: accuracy (95.068%), recall (92.948%), specificity (92.89%), F-Score (92.89%), precision (92.89%), and FPR (2.1%), in that order.
Download full-text PDF |
Source |
---|---|
http://dx.doi.org/10.1177/09287329241296352 | DOI Listing |
Neurochem Res
September 2025
Biology and Health Laboratory, Faculty of Sciences, Ibn Tofail University, Kenitra, Morocco.
Parkinson's disease (PD) is characterized by impairments in motor control following the degeneration of dopamine-producing neurons located in the substantia nigra pars compacta. Environmental pesticides such as Paraquat (PQ) and Maneb (MB) contribute to the onset of PD by inducing oxidative stress (OS). This study evaluated the therapeutic efficacy of moderate physical activity (PA) on both motor and non-motor symptoms in a Wistar rat model of Paraquat and Maneb (PQ/MB) induced PD.
View Article and Find Full Text PDFJ Magn Reson Imaging
September 2025
Neuroimaging Laboratory, School of Medicine, University of Navarra, Pamplona, Spain.
J Magn Reson Imaging
September 2025
Department of Radiology, Huashan Hospital, Fudan University, Shanghai, China.
Background: Parkinson's disease (PD) often presents with lateralized motor symptoms at onset, reflecting asymmetric degeneration of the substantia nigra (SN). Neuromelanin (NM) loss and iron accumulation are hallmarks of SN pathology in PD, but their spatial distribution and interrelationship in PD patients with right-sided (PDR) or left-sided (PDL) motor symptom onset remain unclear.
Purpose: To investigate the spatial vulnerability and interrelationship of NM and iron in the SN among PDR, PDL, and healthy controls (HCs) using MRI.
Comput Methods Biomech Biomed Engin
September 2025
Institute of Radio Physics and Electronics, University of Calcutta, Kolkata, India.
Parkinson's disease (PD) is a neurodegenerative condition that impairs motor functions. Accurate and early diagnosis is essential for enhancing well-being and ensuring effective treatment. This study proposes a deep learning-based approach for PD detection using EEG signals.
View Article and Find Full Text PDFInt J Plant Anim Environ Sci
August 2025
Department of Translational Research, College of Osteopathic Medicine of the Pacific, Western University of Health Sciences, Pomona, CA 91766, USA.
Neurological disorders, such as Alzheimer's disease, Parkinson's disease, epilepsy, spinal cord injuries, and traumatic brain injuries, represent substantial global health challenges due to their chronic and often progressive nature. While allopathic medicine offers a range of pharmacological interventions aimed at managing symptoms and mitigating disease progression, it is accompanied by limitations, including adverse side effects, the development of drug resistance, and incomplete efficacy. In parallel, phytochemicals-bioactive compounds derived from plants-are receiving increased attention for their potential neuroprotective, antioxidant, and anti-inflammatory properties.
View Article and Find Full Text PDF