98%
921
2 minutes
20
Purpose: Incisional hernias (IH) occur after 20-30% of laparotomies. Modern closure techniques including small bite closure and prophylactic mesh augmentation (PMA) demonstrate significant reduction in IH rates. European and American Hernia Society guidelines suggest use of small bite closure and consideration of PMA at elective laparotomy closure but do not make a recommendation for emergency surgery. International surveys demonstrate poor uptake of small bite closure and PMA. This survey aims to assess the uptake of these techniques specifically in emergency abdominal surgery.
Methods: An online, cross-sectional survey was circulated through emergency general surgery (EGS) and abdominal closure networks between June and August 2024. This interrogated surgeons' technical approach to all elements of emergency laparotomy closure including use of wound bundles, small bite, suture-to-wound ratio, suture choice, and PMA.
Results: The survey was completed by 234 general surgeons from 32 countries. Wound bundle components varied between surgeons. Small bite closure was used by 85.8% during midline laparotomy closure but only 42.2% of surgeons used 5 mm wide tissue bites placed every 5 mm. Suture-to-wound ratio was rarely measured (7.7%). A looped PDS (size 0 or 1) was used preferentially (42.7%). Self-locking (15.8%) and antiseptic coated sutures (20.2%) were used infrequently. One in ten surgeons used PMA and most often placed the mesh in the retrorectus space (39.6%).
Conclusion: Uptake of new techniques in emergency laparotomy has been variable and with limited penetrance amongst emergency general surgeons. Many surgeons are using adapted versions of the original descriptions of these approaches.
Download full-text PDF |
Source |
---|---|
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11919986 | PMC |
http://dx.doi.org/10.1007/s00068-025-02804-y | DOI Listing |
Clin Cancer Res
September 2025
Amgen (United States), Thousand Oaks, CA, United States.
Purpose: Tarlatamab is a first-in-class, half-life extended bispecific T-cell engager (BiTE®) immunotherapy targeting delta-like ligand 3 (DLL3) currently approved for the treatment of adult patients with small cell lung cancer (SCLC) with disease progression on or after platinum-based chemotherapy. Here we report tarlatamab exposure-response relationships to inform dose selection in patients with SCLC.
Experimental Design: Pharmacokinetic data were correlated with therapeutic effect [exposure-response (ER) analyses] for efficacy and safety measures using pooled data from DeLLphi-300 and DeLLphi-301 studies.
J Oral Rehabil
September 2025
Center for Advanced Oral Medicine, Hokkaido University Hospital, Sapporo, Japan.
Background: It has not been established how electromyographic (EMG) data of masticatory muscles can estimate bite force (BF) during daily activities at home, such as eating and bruxism, utilising the EMG-BF correlation.
Objective: This study aimed to investigate the relationship between actual BF and BF estimated using corresponding EMG data and additional information on BF and EMG measured on a separate day.
Methods: Participants were 16 volunteers.
PLoS One
September 2025
Marine Mammal and Turtle Division, Southeast Fisheries Science Center, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Miami, Florida, United States of America.
The Rice's whale is among the world's most endangered whales. It has a small population size, low genetic diversity, and is exposed to several anthropogenic threats. In this study, we compiled photographs taken from whale sightings during vessel-based research surveys conducted by the U.
View Article and Find Full Text PDFInt J Pharm X
December 2025
Engineering Research Center of Cell & Therapeutic Antibody, Ministry of Education, China, School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China.
Bispecific T-cell engagers (BiTEs) are small-molecule antibodies that exhibits potent tumoricidal activity but suffer from a short plasma half-life. Mesenchymal stromal cells (MSCs) represent promising delivery vehicles for sustained therapeutic protein expression. In this study, we used human umbilical cord blood-MSCs (hUC-MSCs) as a delivery system to to secrete HER2/CD3 BiTE antibodies, thereby addressing the pharmacokinetic limitations of conventional BiTE therapies.
View Article and Find Full Text PDFPLoS Negl Trop Dis
September 2025
Epidemiology and Public Health Unit, Institut Pasteur du Cambodge, Phnom Penh, Cambodia.
Cambodia is endemic for rabies, a fatal zoonotic viral disease transmitted through dog bites. The Institut Pasteur du Cambodge through its Rabies Prevention Center is the main institution in charge of rabies prevention and surveillance in the country. Its main tool for prevention is post-exposure prophylaxis (PEP) for bite victims.
View Article and Find Full Text PDF