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http://dx.doi.org/10.1080/17460441.2025.2482063 | DOI Listing |
Crit Rev Ther Drug Carrier Syst
January 2025
The emergence of messenger ribonucleic acid (mRNA) vaccines as an alternative platform to traditional vaccines has been accompanied by advances in nanobiotechnology, which have improved the stability and delivery of these vaccines through novel nanoparticles (NPs). Specifically, the development of NPs for mRNA delivery has facilitated the loading, protection and release of mRNA in the biological microenvironment, leading to the stimulation of mRNA translation for effective intervention strategies. Intriguingly, two mRNA vaccines, BNT162b2 (Pfizer-BioNTech) and mRNA-1273 (Moderna), have been permitted for emergency usage authorization to prevent COVID-19 infection by USFDA.
View Article and Find Full Text PDFAm J Speech Lang Pathol
September 2025
American Speech-Language-Hearing Association, Rockville, MD.
Purpose: Since its inception, the National Joint Committee for the Communication Needs of Persons with Severe Disabilities (NJC) has focused specifically on advocating for individuals with significant communication support needs resulting from intellectual disability. The purpose of this review article is to describe the history of terminology used to describe this group of individuals, share the results of a recent survey completed by 102 members of our NJC Network, and discuss the implications of decisions regarding terminology in the NJC's ongoing advocacy efforts.
Method: History of terminology used to describe people with intellectual disability is documented by reviewing the literature, policies, professional organizations, and self-advocacy groups that used various terms from the early 20th century to present day.
Int Urol Nephrol
September 2025
Division of Nursing, Singapore General Hospital, Singapore, Singapore.
Objective: To explore healthcare professionals' perceptions on the implementation of home hemodialysis and self-assisted hemodialysis in Singapore and to identify the perceived barriers, facilitators, and actionable strategies for increasing uptake.
Methods: This is a qualitative explorative study based on semi-structured face-to-face interviews conducted with a multidisciplinary group of 12 healthcare professionals at an acute teaching hospital in Singapore. Thematic analysis was used for data analysis.
J Patient Saf
September 2025
Division of Pulmonary and Critical Care Medicine, Rochester, MN.
Objectives: A framework of high-reliability principles was used to identify, investigate, and mitigate infusion pump safety concerns at a large, multisite health care system. We developed a systematic approach to address challenges associated with overinfusions, underinfusions, and the inability to clear upstream occlusion alarms. We identified 112,875 upstream occlusion events for 389,604 infusion starts (failure rate, 29%) within 6 months.
View Article and Find Full Text PDFOrthop Rev (Pavia)
September 2025
Introduction/background: Complex articular fractures around the knee in the elderly patient present an ongoing challenge regarding optimal treatment. While extensive research has evaluated immediate arthroplasty following fracture of the proximal femur, distal femur, proximal humerus, and elbow, relatively little focus has been given to immediate arthroplasty following complex tibia plateau fractures.
Methods: As seen with many other fractures, arthroplasty can shorten recovery and hospital stay and allow early weight-bearing with improved mobility while minimizing complications and possible future conversion arthroplasty cost.