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Old tests and new paradigms: How to interpret iron studies and related biomarkers for the diagnosis of iron deficiency in adults.
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Department of Medicine, Stellenbosch University, Faculty of Medicine and Health Sciences, Tygerberg Campus, South Africa. Electronic address:
Clinicians need a good understanding of available tools to diagnose iron deficiency (ID). Interpretation of commonly used laboratory tests can be challenging due to the dynamic nature of iron homeostasis and concurrent inflammation, which influence results. The misinterpretation of iron studies, inconsistencies in ID diagnostic guidelines, and low awareness of non-anaemic ID may lead to missed diagnoses and opportunities for treatment.
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In this work we study the effect of the matrix of the source on the spectrum and on the full energy peak efficiency for low energy photons. Using realistic simulations carried out with PENELOPE 2018, including detector resolution, we show that small angle Compton scattering does contribute to the peak count rate, implying the dependence of the matrix effects on the linear attenuation coefficient μ and also on the scattering cross section. We show that the effect of Compton scattering can be removed from the apparent peak, resulting a "clean" peak depending only on μ.
View Article and Find Full Text PDFCardiovascular magnetic resonance imaging: Principles and advanced techniques.
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School of Biomedical Engineering and Imaging Sciences, King's College London, London, United Kingdom; School of Engineering, Pontificia Universidad Católica de Chile, Santiago, Chile; Millennium Institute for Intelligent Healthcare Engineering, Santiago, Chile; Institute for Biological and Medical
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The plasma proteome of plant-based diets: Analyses of 2920 proteins in 49,615 people.
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Cancer Epidemiology Unit, Nuffield Department of Population Health, University of Oxford, Oxford, UK.
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