Publications by authors named "Rachel Lampert"

Purpose Of Review: This review summarizes the psychological effects of consumer wearables in patients with established cardiovascular disease (CVD) and helps to identify remaining challenges that must be resolved to support the appropriate implementation of wearables.

Recent Findings: Consumer wearables (e.g.

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Hypertrophic cardiomyopathy is a common yet under-recognized genetic structural heart condition characterized by left ventricular hypertrophy. Patients may present with obstructive disease characterized by an elevated left ventricular outflow tract gradient or non-obstructive disease. Long established medical and surgical treatment options for patients with obstructive hypertrophic cardiomyopathy and refractory symptoms can be effective in eliminating outflow tract gradients and improving symptoms.

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This American Heart Association/American College of Cardiology scientific statement on clinical considerations for competitive sports participation for athletes with cardiovascular abnormalities or diseases is organized into 11 distinct sections focused on sports-specific topics or disease processes that are relevant when considering the potential risks of adverse cardiovascular events, including sudden cardiac arrest, during competitive sports participation. Task forces comprising international experts in sports cardiology and the respective topics covered were assigned to each section and prepared specific clinical considerations tables for practitioners to reference. Comprehensive literature review and an emphasis on shared decision-making were integral in the writing of all clinical considerations presented.

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Background: Females with hypertrophic cardiomyopathy present at a more advanced stage of the disease and have a higher risk of heart failure and death. The factors behind these differences are unclear. We aimed to investigate sex-related differences in clinical and genetic factors affecting adverse outcomes in the Sarcomeric Human Cardiomyopathy Registry.

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This appropriate use criteria (AUC) document is developed by the American College of Cardiology along with key specialty and subspecialty societies. It provides a comprehensive review of common clinical scenarios where implantable cardioverter-defibrillator (ICD), cardiac resynchronization therapy (CRT), cardiac contractility modulation, leadless pacing, and conduction system pacing therapies are frequently considered. The 335 clinical scenarios covered in this document address ICD indications including those related to secondary prevention, primary prevention, comorbidities, generator replacement at elective replacement indicator, dual-chamber, and totally subcutaneous ICDs, as well as device indications related to CRT, conduction system pacing, leadless pacing, cardiac contractility modulation, and ICD therapy in the setting of left ventricular assist devices (LVADs).

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Article Synopsis
  • - Hypertrophic cardiomyopathy (HCM) was traditionally seen as caused by rare, high-risk single-gene changes, but new research indicates common low-risk variants (LowSVs) also play a significant role in the disease.
  • - In a study of over 6000 patients, 12 LowSVs were discovered, which are relatively common in the general population and more prevalent in HCM patients, suggesting they may influence disease severity and risk.
  • - While LowSVs alone are linked to a later onset of HCM and fewer complications, their presence alongside more severe genetic variants increases health risks significantly.
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  • The study investigates how acute psychological stress impacts cardiovascular disease (CVD) mortality, focusing on autonomic dysfunction as indicated by electrocardiographic measures.
  • In a cohort of 765 participants with stable CVD, researchers monitored heart rate variability (HRV) during stress tests and found a significant association between decreased HRV during stress and a higher risk of CVD death.
  • The findings suggest that both stress-induced decreases in HRV and low resting HRV independently increase the risk of CVD mortality, highlighting the need for further research on managing autonomic dysfunction to improve health outcomes.
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Article Synopsis
  • A new machine learning algorithm was developed to predict all-cause mortality and heart failure hospitalization in patients with implantable cardioverter-defibrillators (ICDs), aiming to improve personalized risk assessments compared to traditional methods.
  • The study used a large cohort from the Veterans Health Administration, analyzing data to identify risk factors and utilizing random forest techniques for accurate predictions over 3-month and 1-year intervals.
  • Results showed strong predictive accuracy, with receiver-operating characteristic curve values indicating the model's effectiveness in distinguishing patient outcomes based on baseline demographics and ICD data.
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This study explores the genetic and epidemiologic correlates of long-term photoplethysmography-derived pulse rate variability (PRV) measurements with anxiety disorders. Individuals with whole-genome sequencing, Fitbit, and electronic health record data (N = 920; 61,333 data points) were selected from the All of Us Research Program. Anxiety polygenic risk scores (PRS) were derived with PRS-CS after meta-analyzing anxiety genome-wide association studies from three major cohorts- UK Biobank, FinnGen, and the Million Veterans Program (N =364,550).

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Background: It has been hypothesized that both atrial fibrillation (AF) and medications for AF are poorly tolerated in athletes.

Objective: The purpose of this study was to determine the impact of AF and AF treatments on sports performance.

Methods: An Internet-based survey, initiated via StopAfib.

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Background: An improved understanding of the natural history in NYHA functional class I patients with obstructive hypertrophic cardiomyopathy (oHCM) is needed.

Objectives: Using a multicenter registry (SHaRe [Sarcomeric Human Cardiomyopathy Registry]), this study described the natural history in patients with oHCM who were classified as NYHA functional class I at the initial visit compared with patients classified as NYHA functional class II and reported baseline characteristics associated with incident clinical events.

Methods: Incident events assessed included a composite of NYHA functional class III to IV symptoms, left ventricular ejection fraction <50%, atrial fibrillation, stroke, ventricular arrhythmias, septal reduction therapy, ventricular assist device or transplantation, or death.

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The rapid growth in consumer-facing mobile and sensor technologies has created tremendous opportunities for patient-driven personalized health management. The diagnosis and management of cardiac arrhythmias are particularly well suited to benefit from these easily accessible consumer health technologies. In particular, smartphone-based and wrist-worn wearable electrocardiogram (ECG) and photoplethysmography (PPG) technology can facilitate relatively inexpensive, long-term rhythm monitoring.

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Article Synopsis
  • Historically, people with Hypertrophic Cardiomyopathy (HCM) were discouraged from playing intense competitive sports due to fears of sudden death.
  • Recent studies indicate that individuals with HCM engaging in vigorous sports may not face a higher risk of heart arrhythmias compared to less active individuals.
  • Current guidelines are adapting to recommend personalized assessments and shared decision-making for HCM athletes looking to return to their sports.
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Article Synopsis
  • Septal reduction therapy (SRT) significantly improves symptoms for patients with obstructive hypertrophic cardiomyopathy (HCM), but its long-term results and predictors of adverse outcomes still need more study.* -
  • An analysis of data from the SHARE registry revealed that among 1,832 patients who underwent SRT, the 30-day mortality rate was low at 0.4%, and after approximately 6.8 years, rates for HCM-related death, heart failure, and ventricular arrhythmias were relatively low.* -
  • Key findings included that older age at SRT increases risks for HCM death and heart failure outcomes, while female patients showed higher susceptibility to heart failure complications post-treatment.*
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  • The LIVE-LQTS study aimed to investigate whether vigorous exercise increases the risk of ventricular arrhythmias in individuals with congenital long QT syndrome (LQTS) by tracking participants' activity and health events over three years.
  • Among 1,413 participants, 52% engaged in vigorous exercise, and the study found similar rates of serious cardiac events (2.6% in vigorous exercisers vs. 2.7% in non-vigorous) suggesting that vigorous exercise may not significantly increase risk for these individuals.
  • The results had a hazard ratio of 0.97, indicating that vigorous exercisers experienced similar or potentially lower rates of adverse events than those who did not exercise vigorously, providing insight into safe exercise practices for LQ
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Background: Wearables are increasingly used by patients with atrial fibrillation (AF) for symptom monitoring and health management, but their impact on patient health care use and psychological well-being is not well understood.

Methods And Results: In this retrospective, propensity-matched study of patients with AF, survey and electronic health record data were merged to compare AF-specific health care use (outpatient/inpatient visits, rhythm-related testing, and procedures) and informal health care use (telephone calls and patient portal messages) over a 9-month period between wearable users and nonusers. We also examined the effects of wearable cardiac monitoring features (eg, heart rate alerts, irregular rhythm notification, and ECG) on patient behavior and well-being.

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  • Mental stress-induced myocardial ischemia (MSIMI) is linked to poorer heart health outcomes in people with coronary artery disease, but how stress affects heart function is not fully understood.
  • This study involved 735 patients and looked at their heart rate variability (HRV) during stress to see if low HRV indicates autonomic dysfunction associated with MSIMI.
  • Results showed that patients with low HRV during stress had significantly higher odds of experiencing MSIMI, suggesting that stress-related autonomic dysfunction could contribute to heart issues in these patients.
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  • The document outlines guidelines for diagnosing and managing cardiac arrhythmias in athletes, given the rise in sports participation among youth and adults.
  • It highlights the importance of expert risk assessments based on athlete symptoms to ensure safe return to sports while minimizing restrictions.
  • Key topics covered include treatment strategies, shared decision-making, emergency planning, and recommendations for future research in managing these conditions.
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