Recent Advances in Surface-Enhanced Raman Scattering for Pathogenic Bacteria Detection: A Review.

Bacterial infection is one of the common infectious diseases in clinical practice, and the research on efficient detection of bacteria has attracted much attention in recent years. Currently, the traditional detection methods of bacteria are mainly based on cell culturing, microscopic examination, and molecular biology techniques, all of which have the disadvantages of complex operation and time-consuming. Surface-enhanced Raman spectroscopy (SERS) technology has shown prominent advantages in bacterial detection and identification because of the merit of high-sensitivity, fast detection and unique molecular fingerprint spectrum. This paper mainly investigates and discusses the application of SERS in bacterial detection, and systematically reviews the progress of SERS applications, including nano-enhanced dielectric materials of SERS, signal amplification of SERS labeled molecules, and the integration of SERS with microfluidic technology. Finally, the paper analyzes the challenges associated with the application of SERS in bacterial detection and offers insights into future development trends.