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| http://dx.doi.org/10.1080/17446651.2025.2480695 | DOI Listing |
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Antiarthritic activities of berberine in a rat model of gouty arthritis.
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Department of Therapeutic Chemistry, National Research Centre, 33 El-Bohouth St., Dokki, Cairo, 12622, Egypt.
Gouty arthritis (GA) is an inflammatory arthritic disorder that is characterized by intense, acute inflammatory responses, such as synovitis and arthritis that occur due to articular deposition of monosodium urate (MSU) crystals. This study has compared the therapeutic potentials of either Berberine (BERB) or Paracetamol (Para) on MSU-induced inflammation in rat model of Gouty arthritis (GA). GA was induced by "intra-articular" injection of MSU suspension (20 mg/ml) inside the knee joint of the rat's right limb.
View Article and Find Full Text PDFCis-resveratrol blocks crystal-induced NLRP3 inflammasome activation via the TRPV4-Ca²⁺-phagocytosis-ROS axis.
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School of Pharmaceutical Sciences, South-Central Minzu University, Wuhan 430065, PR China. Electronic address:
Background: Inflammation is a vital biological defense mechanism, yet uncontrolled or prolonged inflammation can cause tissue damage. The NLRP3 inflammasome, a central component of innate immunity, drives inflammation by activating caspase-1 and promoting the release of cytokines like IL-1β. Monosodium urate (MSU) crystals are potent NLRP3 inflammasome activators implicated in diseases such as gout.
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Department of Microbiology, School of Basic Medical Sciences, Xinjiang Medical University, Urumqi 830000, China.
Hyperuricemia, associated with gout and chronic kidney disease, underscores the need for novel therapies. Recent studies suggest that the gut microbiota may play a role in the pathogenesis of HUA, with certain probiotics demonstrating potential in reducing urate levels. Notably, Limosilactobacillus fermentum M5e exhibits exceptional in vitro uric acid degradation, yet its in vivo mechanisms remain unexplored.
View Article and Find Full Text PDFBackground: Interleukin-1 receptor-associated kinase 4 (IRAK4) is a pivotal mediator of toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) signaling, critically involved in innate immune activation and pro-inflammatory cytokine production. Dysregulated IRAK4 activity contributes to chronic inflammation in both immune and non-immune cells. In this study, we evaluated the immunomodulatory potential of a selective IRAK4 inhibitor on monosodium urate (MSU) crystals-stimulated macrophages and xanthine-challenged HepG2 cells to assess its therapeutic potential.
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