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This article aimed to assess the efficacy of surgical treatments, particularly arthrodesis with C2 nerve transection, in patients with atlantoaxial osteoarthritis (AAOA). Data of patients with AAOA who underwent surgical treatment between January 2020 and November 2023 were retrospectively collected. Of 11 patients with AAOA, nine underwent fusion surgery, and two underwent decompression surgery. C2 root transection on the symptomatic side was performed in all fusion cases. C2 root transection was not performed during decompression. All patients experienced immediate and persistent pain relief after surgery. Four patients who underwent fusion surgery reported a complete disappearance of pain. Four patients who underwent fusion surgery reported some numbness of the scalp, but it did not affect the quality of daily activities or cause significant discomfort. One patient who underwent decompression surgery reported residual tingling sensation and hyperesthesia of the scalp. We concluded that C1-2 fusion surgery is an excellent surgical treatment option and should be primarily considered for patients with refractory AAOA. C2 root transection on the symptomatic side can completely alleviate pain at the expense of minor scalp anesthesia. Decompressive-only surgery is not recommended but can be considered in strictly selected patients.
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http://dx.doi.org/10.1038/s41598-025-92699-x | DOI Listing |
Front Immunol
September 2025
Department of Thoracic Surgery, Shenzhen People's Hospital (The First Affiliated Hospital, Southern University of Science and Technology; The Second Clinical Medical College, Jinan University), Shenzhen, Guangdong, China.
Background: Lung cancer remains the leading cause of cancer-related mortality globally, primarily due to late-stage diagnosis, molecular heterogeneity, and therapy resistance. Key biomarkers such as EGFR, ALK, KRAS, and PD-1 have revolutionized precision oncology; however, comprehensive structural and clinical validation of these targets is crucial to enhance therapeutic efficacy.
Methods: Protein sequences for EGFR, ALK, KRAS, and PD-1 were retrieved from UniProt and modeled using SWISS-MODEL to generate high-confidence 3D structures.
JB JS Open Access
September 2025
Shriners Children's Philadelphia, Philadelphia, Pennsylvania.
Background: Vertebral body tethering (VBT) offers an alternative treatment for patients with idiopathic scoliosis. We present our finalized Food and Drug Administration Investigational Device Exemption (IDE) study results on VBT.
Methods: We retrospectively reviewed patients with Lenke Type IA/B curves who underwent VBT between 2011 and 2015.
Rev Cardiovasc Med
August 2025
Department of Cardiology, University Hospitals of Leicester NHS Trust, Glenfield Hospital, LE3 9QP Leicester, UK.
Adult congenital heart disease (ACHD) constitutes a heterogeneous and expanding patient cohort with distinctive diagnostic and management challenges. Conventional detection methods are ineffective at reflecting lesion heterogeneity and the variability in risk profiles. Artificial intelligence (AI), including machine learning (ML) and deep learning (DL) models, has revolutionized the potential for improving diagnosis, risk stratification, and personalized care across the ACHD spectrum.
View Article and Find Full Text PDFMed Sci Monit
September 2025
Department of Orthopedics, Ansteel General Hospital, Anshan, Liaoning, China.
BACKGROUND Degenerative cervical spondylotic myelopathy (CSM) is an age-related degenerative condition of the vertebral bodies, discs, and ligaments that can cause pressure on the spinal cord and nerves. Anterior cervical corpectomy and fusion is a widely used surgical approach for treating CSM, aiming to decompress the spinal cord, restore vertebral alignment, and improve fusion rates, thus providing relief to affected patients. This study was a neurological and biomechanical evaluation of 72 patients with degenerative CSM at 3, 6, and 12 months following anterior cervical corpectomy and fusion.
View Article and Find Full Text PDFJ Neurol Surg A Cent Eur Neurosurg
September 2025
Neurosurgery, InnKlinikum gkU Altötting und Mühldorf, Altötting, Germany.
Purpose: This study aimed to evaluate clinical and radiological outcomes of patients who underwent anterior cervical discectomy and fusion (ACDF) without additional anterior plate fixation.
Methods: A retrospective single-center analysis was conducted. Clinical outcomes were assessed by the Visual Analog Scale (VAS) scores, Neck Disability Index (NDI), and Odom's criteria.