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Neurotechnological interfaces have the potential to create new forms of human-machine interactions, by allowing devices to interact directly with neurological signals instead of via intermediates such as keystrokes. Surface electromyography (sEMG) has been used extensively in myoelectric control systems, which use bioelectric activity recorded from muscles during contractions to classify actions. This technology has been used primarily for rehabilitation applications. In order to support the development of myoelectric interfaces for a broader range of human-machine interactions, we present an sEMG dataset obtained during key presses in a typing task. This fine-grained classification dataset consists of 16-channel bilateral sEMG recordings and key logs, collected from 19 individuals in two sessions on different days. We report baseline results on intra-session, inter-session and inter-subject evaluations. Our baseline results show that within-session accuracy is relatively high, even with simple learning models. However, the results on between-session and between-participant are much lower, showing that generalizing between sessions and individuals is an open challenge.
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http://dx.doi.org/10.1038/s41597-025-04763-w | DOI Listing |
Nucleic Acids Res
September 2025
Department of Pathology, Microbiology and Immunology, College of Medicine, University of Nebraska Medical Center, 985900 Nebraska Medical Center, Omaha, NE 68198-5900, United States.
The global antibiotic resistance issue constitutes a driving force for developing host defense antimicrobial peptides (AMPs) into a new generation of antibiotics. To facilitate this development, we report the antimicrobial peptide database version 6 (APD6) with (i) the consolidated database platform, (ii) the most comprehensive AMP information pipeline (AMPIP), and (iii) the expanded wheel of function. As of 18 March 2025, the APD6 platform housed records for 5188 peptides, including 3306 natural, 1380 synthetic, and 239 predicted AMPs with systematic classification schemes for each group.
View Article and Find Full Text PDFFront Digit Health
August 2025
Department of Ophthalmology, Stanford University, Palo Alto, CA, United States.
Introduction: Vision language models (VLMs) combine image analysis capabilities with large language models (LLMs). Because of their multimodal capabilities, VLMs offer a clinical advantage over image classification models for the diagnosis of optic disc swelling by allowing a consideration of clinical context. In this study, we compare the performance of non-specialty-trained VLMs with different prompts in the classification of optic disc swelling on fundus photographs.
View Article and Find Full Text PDFNeurotrauma Rep
August 2025
Institute of Acupuncture and Moxibustion, China Academy of Chinese Medical Sciences, Beijing, China.
Accurate differentiation between persistent vegetative state (PVS) and minimally conscious state and estimation of recovery likelihood in patients in PVS are crucial. This study analyzed electroencephalography (EEG) metrics to investigate their relationship with consciousness improvements in patients in PVS and developed a machine learning prediction model. We retrospectively evaluated 19 patients in PVS, categorizing them into two groups: those with improved consciousness ( = 7) and those without improvement ( = 12).
View Article and Find Full Text PDFThe morphological patterns of lung adenocarcinoma (LUAD) are recognized for their prognostic significance, with ongoing debate regarding the optimal grading strategy. This study aimed to develop a clinical-grade, fully quantitative, and automated tool for pattern classification/quantification (PATQUANT), to evaluate existing grading strategies, and determine the optimal grading system. PATQUANT was trained on a high-quality dataset, manually annotated by expert pathologists.
View Article and Find Full Text PDFBJUI Compass
September 2025
Department of Radiation Oncology and Image-Applied Therapy, Graduate School of Medicine Kyoto University Kyoto Kyoto Japan.
Objectives: To develop a novel risk score (RS) model to predict the probability of progression to castration-resistant prostate cancer (PCa) (CRPC) after intensity-modulated radiation therapy (IMRT) for patients with high- and very high-risk PCa according to the National Comprehensive Cancer Network (NCCN) risk classification, since accurate prediction of the clinical outcome of definitive radiation therapy for patients with high- and very high-risk PCa remains challenging due to its heterogeneity.
Materials And Methods: We conducted a retrospective review of 600 patients with high- and very high-risk PCa treated with IMRT at our institution. They were randomly divided into discovery (n = 300) and validation (n = 300) cohorts.