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Euphthymifolols A-E (-), five undescribed jatrophane diterpenoids feature with a typically 5/12 bicyclic skeleton, were characterised from the aerial parts of L. A thorough analysis of the spectroscopic data and biosynthetic pathway elucidated their planar structures and stereoconfiguration. Compound exhibited moderate nitric oxide (NO) inhibitory activity (IC 63.3 ± 1.94 μM) against LPS-induced BV-2 microglia cells.
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http://dx.doi.org/10.1080/14786419.2025.2478303 | DOI Listing |
Nat Prod Res
March 2025
College of Traditional Chinese Medicine, Shandong University of Traditional Chinese Medicine, Jinan, China.
Euphthymifolols A-E (-), five undescribed jatrophane diterpenoids feature with a typically 5/12 bicyclic skeleton, were characterised from the aerial parts of L. A thorough analysis of the spectroscopic data and biosynthetic pathway elucidated their planar structures and stereoconfiguration. Compound exhibited moderate nitric oxide (NO) inhibitory activity (IC 63.
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