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Importance: Community pharmacies are crucial for public health, providing essential services such as medication dispensing, vaccinations, and point-of-care testing. Addressing disparities in pharmacy access, particularly in underserved rural and low-income areas, is critical for health equity.
Objective: To identify areas in the US at risk of becoming pharmacy deserts through the development of a novel pharmacy vulnerability index.
Design, Setting, And Participants: This population-based cross-sectional study in the contiguous 48 states performed geographic information systems analysis of pharmacy data from the National Council for Prescription Drug Programs (NCPDP) dataQ. Participants included all open-door pharmacies (community or retail pharmacies open to the general public without restrictions on who can access its services) in the US as of February 2024. Statistical analysis was performed from July to August 2024.
Exposure: The primary exposure was travel time to pharmacies across the US.
Main Outcomes And Measures: A pharmacy desert was defined as a census tract where the travel time to the nearest pharmacy exceeds the supermarket access time for that region and urbanicity level. Building on this definition, a pharmacy vulnerability index was developed, which indicates the number of pharmacies that would need to close for a census tract to become a pharmacy desert. Tracts with a pharmacy vulnerability index of 1, depending solely on a single pharmacy for access, were identified as at risk of becoming deserts. Subpopulation totals and percentages living in pharmacy deserts or relying on keystone pharmacies were computed, and then stratified by urbanicity and race.
Results: Among 321.3 million individuals (39.7 million [12.3%] Black, 59.0 million [18.2%] Hispanic, 195.0 million [60.3%] White) in the contiguous US, 57.1 million (17.7%) were identified as living in pharmacy deserts, with 28.9 million (8.9%) additionally relying on a single pharmacy for access. Small rural areas were particularly affected, with a higher dependency on single pharmacies (4.1 million individuals [14.3%]).
Conclusions And Relevance: In this cross-sectional study of pharmacy access in the US, significant disparities in pharmacy access were identified, especially pronounced in small rural areas. Targeted policy interventions, such as incremental reimbursement rates or other monetary incentives, are needed to ensure the financial sustainability of pharmacies that serve as the sole source of pharmacy services in at-risk areas.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC11907307 | PMC |
http://dx.doi.org/10.1001/jamanetworkopen.2025.0715 | DOI Listing |
Health Promot Int
September 2025
Faculty of Pharmacy, Pham Ngoc Thach University of Medicine, 02 Duong Quang Trung Street, Hoa Hung Ward, Ho Chi Minh City 700000, Vietnam.
Health literacy (HL) is a fundamental factor in raising health awareness and self-management, especially in contexts with increasingly complicated health systems. Its accurate and culturally appropriate measurement is necessary to support effective medical interventions. Accordingly, we translated the Health Literacy Questionnaire (HLQ) into Vietnamese and analysed its psychometric properties on the basis of data derived from respondents who completed the translated instrument.
View Article and Find Full Text PDFDrug Dev Res
September 2025
Tianjin Key Laboratory on Technologies Enabling Development of Clinical Therapeutics and Diagnostics, School of Pharmacy, Tianjin Medical University, Tianjin, P. R. China.
The structural modification and derivatization of natural products represent an essential pathway for pharmaceutical innovation in the management of depression. The 8-phenyl tetrahydroisoquinoline, as a parent core, was obtained from magnoflorine by a structural simplification strategy. The present report details the synthesis and antidepressant activity studies of 8-phenyl-THIQ analogs.
View Article and Find Full Text PDFDiabetes Metab Syndr Obes
August 2025
Department of Pharmacy Practice, College of Pharmacy, Qassim University, Qassim, 51452, Saudi Arabia.
Purpose: Glucagon-like peptide-1 (GLP-1) receptor agonists and sodium-glucose cotransporter-2 (SGLT-2) inhibitors represent major advancements in the management of type 2 diabetes. However, many patients remain suboptimally managed with these therapies. This underutilization highlights the need for practical implementation strategies in real-world settings.
View Article and Find Full Text PDFCureus
August 2025
Medical Oncology, Mohammed VI University Hospital of Marrakech, Marrakesh, MAR.
Sebaceous carcinoma of the breast is a rare and poorly understood variant of metaplastic breast carcinoma. Its histogenesis, clinical behavior, and optimal management remain unclear due to the limited number of reported cases. We report the case of a 78-year-old woman presenting with a six-month history of a right axillary mass and inflammatory changes in the right breast.
View Article and Find Full Text PDFCureus
August 2025
Physical Medicine and Rehabilitation, Faculty of Medicine and Pharmacy, Mohammed I University, Oujda, MAR.
This case report describes the functional outcomes of a proprioceptive rehabilitation protocol for primary prevention in a 31-year-old patient with L5-S1 radiculopathy sequelae confirmed by electroneuromyography and associated ankle proprioceptive deficit. The patient underwent a seven-week proprioceptive rehabilitation protocol comprising 10 supervised sessions, with a six-month follow-up period. Assessment tools included the Foot and Ankle Ability Measure (FAAM), the single-leg balance test with eyes closed, and the visual analog scale (VAS) for perceived stability.
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