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This randomized controlled trial investigated the effect of concurrent training (CT) on the mental health of inactive academics and examined associations between changes in stress (effort-reward imbalance and general stress), depressive symptoms and systemic inflammation. Fifty-nine inactive academics were randomly assigned to a CT ( = 29) or control (non-exercise) group ( = 30). CT performed supervised group training at an onsite facility 3 times per week for 14-weeks. Symptoms of depression, anxiety, and stress (job specific and general), and systemic inflammation (Interleukin-6 and Tumor necrosis factor-α) were measured pre and post intervention, and ecological momentary assessment of wellness measures was conducted before and during the last 2-weeks of the intervention. An effort-reward imbalance was evident before (CT, 1.26 ± 0.37; control; 1.22 ± 0.47) and after (CT, 1.16 ± 0.31; control; 1.21 ± 0.35) training, with no interaction effect ( > .05). Following CT, symptoms of depression decreased in the CT group ( = .009) with no change in control ( = .463). There were positive correlations between changes in stress and symptoms of depression ( < .05), but no relationship between changes in systemic inflammation and changes in stress or depression ( > .05). CT can decrease symptoms of depression in inactive academics despite the continued presence of an effort-reward imbalance. These findings may be important for universities aiming to improve the mental health of currently inactive academics.
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http://dx.doi.org/10.1080/02701367.2025.2461322 | DOI Listing |
Surv Ophthalmol
September 2025
Yong Loo Lin School of Medicine, National University of Singapore, Singapore; National Healthcare Group Eye Institute, Tan Tock Seng Hospital, Singapore; Lee Kong Chian School of Medicine, Nanyang Technological University, Singapore; Programme for Ocular Inflammation & Infection Translational Resear
The Choroidal Vascularity Index (CVI), derived from optical coherence tomography (OCT), has emerged as a potential biomarker for detecting vascular changes. Understanding its variability across physiological states, ocular conditions, and systemic diseases is crucial for its integration into clinical practice. We evaluated variations in CVI across different physiological states (e.
View Article and Find Full Text PDFBMJ Open
September 2025
Department for Life Quality Studies, Alma Mater Studiorum University of Bologna, Rimini, Italy.
Objective: This study aims to analyse the barriers and facilitators towards an implementation of active breaks (ABs) intervention inside the workplace.
Methods: This study used a mixed-methods approach, incorporating virtual focus groups and an online questionnaire, conducted among the workers of Alma Mater Studiorum - University of Bologna (Italy). A total of 30 participants (N=30), including administrative and academic staff, PhD candidates, specialised trainees and research fellows, were involved in the study.
J Physician Assist Educ
September 2025
Rachel L. Clark, PA-C, MPAS, MPH, is an urgent care physician assistant practicing in Green Bay, Wisconsin.
Introduction: Physical activity positively affects physical, mental, and emotional health and enhances academic performance. However, many students fail to meet recommended activity levels. Research indicates that graduate students' physical inactivity rates align with national averages, with sedentary behavior increasing due to academic demands.
View Article and Find Full Text PDFCrit Rev Oncol Hematol
September 2025
Student Research Committee, Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran.. Electronic address:
Epigenetic regulation is fundamental to hematopoiesis, influencing stem cell fate, lineage commitment, and the development of hematologic diseases. Recent technological innovations have transitioned from traditional genetic editing towards programmable, reversible epigenetic modulation without altering the DNA sequence. This review explores the evolution of epigenetic editing platforms, from zinc finger proteins and TALEs to the transformative CRISPR-dCas9 system, and introduces next-generation technologies leveraging dCas12, dCas13, and modular RNA-guided systems.
View Article and Find Full Text PDFBMJ Open
August 2025
Child Health and Physical Activity Laboratory, School of Occupational Therapy, University of Western Ontario, London, Ontario, Canada
Introduction: Mental health conditions are a major public health challenge. Though typically diagnosed in adolescence, these conditions may arise during early childhood. Considerable evidence shows that engagement in healthy movement behaviours (ie, regular physical activity, reduced sedentary behaviour and sufficient sleep) is associated with a lower risk of mental health conditions in adolescents and adults.
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