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http://dx.doi.org/10.7754/Clin.Lab.2024.241016 | DOI Listing |
Obes Rev
August 2025
Molecular Physiology Laboratory, Department of Biochemistry, Bharathiar University, Coimbatore, Tamil Nadu, India.
Dietary fat taste, a distinct gustatory modality that greatly influences food choice and energy intake, is primarily mediated by the lingual receptors CD36 and GPR120. Recent studies show that both short-term and long-term physical activity can modulate sensitivity to long-chain fatty acids, which can lead to changes in dietary patterns and preferences for high-fat foods. This review specifically examines the effects of exercise on the perception of fat taste by integrating findings from human and animal studies that examine alterations in detection thresholds, suprathreshold intensity ratings, and hedonic responses to fatty stimuli.
View Article and Find Full Text PDFCurr Dev Nutr
July 2025
Department of Health and Sport Sciences, TUM School of Medicine and Health, Technical University of Munich, Munich, Germany.
Background: Acute exercise alters appetite-regulating hormones like peptide tyrosine tyrosine (PYY), glucagon-like peptide-1 (GLP-1), and ghrelin, suppressing appetite and reducing food intake. The effect of exercise on hunger and satiety has been shown to vary by body composition, sex, and habitual physical activity, but the influence of aging is less understood.
Objectives: We aimed to examine age-related differences in the effect of acute exercise on appetite-regulating hormones.
Metabolites
June 2025
Department of Endocrinology and Metabolism, Amsterdam University Medical Center, Location AMC, University of Amsterdam, 1105 AZ Amsterdam, The Netherlands.
N-lactoyl-phenylalanine (Lac-Phe), an exercise-induced metabolite, has been shown to reduce food intake, decrease body weight and adiposity, and improve glucose homeostasis without affecting energy expenditure. Until now, Lac-Phe has mainly been investigated in blood plasma, showing its appetite-suppressing effects. Interestingly, these beneficial effects were caused by a temporary increase in Lac-Phe levels after exercise.
View Article and Find Full Text PDFDiabetes Metab Res Rev
July 2025
Biomedical Research Center, QU Health, Qatar University, Doha, Qatar.
N-lactoyl amino acids (Lac-AA) form an emerging class of metabolites that have gained significant attention in recent years due to their ubiquitous presence in different biological systems and potential roles in various biochemical processes. This narrative review aims to provide a comprehensive overview of the current understanding of Lac-AA, emphasising their biosynthesis, physiological roles, and potential implications in various diseases. We discuss the discovery of Lac-AA as signalling molecules, and their involvement in exercise-induced appetite suppression, energy metabolism, and other pathways.
View Article and Find Full Text PDFPhysiol Behav
July 2025
Centre for Physical Activity, Sport and Exercise Sciences, Coventry University, CV1 2DS, UK. Electronic address:
Introduction: Cold-water immersion is a popular method typically used to reduce exercise induced muscle damage and improve health and wellbeing. Despite these benefits, there is emerging evidence to suggest the temperature of the water exposure can influence energy intake in the subsequent hours. The study aim was to investigate the influence of water temperature on energy expenditure and post-water immersion ad-libitum energy intake in resting adults.
View Article and Find Full Text PDF