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Introduction: Although not frequent, the recurrence of seminoma later than 5-10 years after orchiectomy has been reported. We report a case of recurrence of seminoma 48 years after orchiectomy, with metastasis to the para-aorta that was treated with chemotherapy.
Case Presentation: An 83-year-old man had an incidentally enlarged para-aortic lymph node noted on computed tomography. Needle biopsy revealed metastasis from a seminoma that had been treated with orchiectomy at age 35. Chemotherapy was introduced but discontinued after the first course due to side effects. However, a decrease in fluorodeoxyglucose accumulation on positron emission tomography was observed, with no subsequent re-enlargement of the tumor.
Conclusion: Chemotherapy was introduced for an elderly patient with the longest known late relapse. Dose reduction should be considered in cases with good prognosis, considering factors such as age.
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http://dx.doi.org/10.1002/iju5.70000 | DOI Listing |
Urologie
September 2025
Klinik für Strahlentherapie und Radioonkologie, Universitätsspital Basel, Basel, Schweiz.
Background: Stage IIA/B seminoma is cured in over 90% of cases with standard therapies (polychemotherapy, large-volume radiotherapy). However, these treatments are associated with potential late toxicities.
Materials And Methods: This article addresses current developments from a urological-surgical and radiotherapeutic perspective in the treatment of stage IIA/B seminoma.
Transl Androl Urol
July 2025
Department of Pathology & Laboratory Medicine, University of Rochester Medical Center, Rochester, NY, USA.
Background: Testicular tumors are rare, particularly in aged men. Indeed, germ cell tumors occur mostly in the young population. Importantly, few studies have systematically characterized testicular tumors, other than lymphomas and spermatocytic tumor, diagnosed in the elderly.
View Article and Find Full Text PDFFront Med (Lausanne)
June 2025
Department of Genitourinary Oncology, Maria Skłodowska-Curie National Research Institute of Oncology, Warsaw, Poland.
Testicular cancer, predominant among young males, poses a significant healthcare challenge with varying incidence rates across European regions. Germ cell tumors (GCTs), constituting 95% of the cases, can be divided into seminoma and non-seminomatous germ cell tumors (NSGCTs). Metastases commonly occur in the lungs, lymph nodes, liver, bone, and brain.
View Article and Find Full Text PDFSurg Case Rep
July 2025
Department of Thoracic Surgery and Breast Surgery, Asahikawa Medical University Hospital, Asahikawa, Hokkaido, Japan.
Introduction: Although seminomas typically arise in the testes, primary mediastinal seminomas are classified as extragonadal germ cell tumors. Diagnosis is often challenging and requires not only blood tests and imaging but also a tumor biopsy. However, diagnosis may be particularly difficult when the tumor shows nonspecific pathological features or is accompanied by granulomatous changes.
View Article and Find Full Text PDFCureus
May 2025
Department of General Thoracic Surgery, Osaka Toneyama Medical Center, Toyonaka, JPN.
Adenocarcinoma rarely manifests as a bulky, invasive mediastinal tumor. Even more unusual is when such a tumor, initially diagnosed as another malignancy on biopsy, is later identified as an adenocarcinoma of unknown primary origin. A 46-year-old man with no prior history of malignancy was diagnosed with primary mediastinal seminoma and received chemotherapy before being referred to our hospital.
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