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Modern machine learning often relies on optimizing a neural network's parameters using a loss function to learn complex features. Beyond training, examining the loss function with respect to a network's parameters (i.e., as a loss landscape) can reveal insights into the architecture and learning process. While the local structure of the loss landscape surrounding an individual solution can be characterized using a variety of approaches, the global structure of a loss landscape, which includes potentially many local minima corresponding to different solutions, remains far more difficult to conceptualize and visualize. To address this difficulty, we introduce LossLens, a visual analytics framework that explores loss landscapes at multiple scales. LossLens integrates metrics from global and local scales into a comprehensive visual representation, enhancing model diagnostics. We demonstrate LossLens through two case studies: visualizing how residual connections influence a ResNet-20, and visualizing how physical parameters influence a physics-informed neural network solving a simple convection problem.
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http://dx.doi.org/10.1109/MCG.2024.3509374 | DOI Listing |
Mol Biol Rep
September 2025
Cytogenetics and Molecular Genetics Lab, Pathology Unit, Medical Division (BARC Hospital), Bhabha Atomic Research Centre, Anushakti Nagar, Mumbai, India.
Background: Hearing loss (HL) is one of the most common congenital anomalies and is a complex etiologically diverse condition. Molecular genetic characterization of HL remains challenging owing to the high genetic heterogeneity. This study aimed to screen for potential disease-causing genetic variations in a cohort of Indian patients with congenital bilateral severe-to-profound sensorineural HL.
View Article and Find Full Text PDFiScience
September 2025
Department of Physical Geography and Ecosystem Science, Lund University, 223 62 Lund, Sweden.
Forest loss, fragmentation, and transformation negatively impact forest biodiversity and ecosystem functionality worldwide. Improving landscape intactness and connectivity through restoration is critical. Determining where to restore remains, however, a challenge.
View Article and Find Full Text PDFJ Anim Ecol
September 2025
Terrestrial Ecology Research Group, Department of Ecology and Ecosystem Management, School of Life Sciences, Technische Universität München, Freising, Germany.
Land-use change and intensification are major drivers of biodiversity loss, yet their effects on diversity have usually been studied within a single habitat type or land-use category, limiting our understanding of cross-habitat patterns. Moths, a species-rich taxon worldwide, represent a significant portion of the biodiversity in both temperate forests and grasslands, functioning as pollinators and herbivores. While increasing land-use intensity (LUI) in both habitats is expected to negatively impact moth assemblages, the strength of this effect remains uncertain.
View Article and Find Full Text PDFEnviron Manage
September 2025
TEMSUS Research Group, Catholic University of Ávila, Ávila, Spain.
Forests have been increasingly affected by natural disturbances and human activities. These impacts have caused habitat fragmentation and a loss of ecological connectivity. This study examines potential restoration pathways that reconnect the five largest forest cores in the Castilla y León region of Spain.
View Article and Find Full Text PDFCell Death Differ
September 2025
Department of Neurology, Tianjin Neurological Institute, Tianjin Medical University General Hospital, Tianjin, China.
Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system (CNS) characterized by inflammatory demyelination and progressive neurodegeneration. Although current disease-modifying therapies modulate peripheral autoimmune responses, they are insufficient to fully prevent tissue specific neuroinflammation and long-term neuronal and oligodendrocyte loss. Growing evidence implicates various regulated cell death (RCD) pathways, including apoptosis, necroptosis, pyroptosis, and ferroptosis, not only as downstream consequences of chronic inflammation, but also as active drivers of demyelination, axonal injury, and glial dysfunction in MS.
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