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The occurrence of rock burst is related to the physical properties of coal-bearing strata. Under the same mining conditions, the excavation of soft coal seams at 1000 m or deeper has a lower risk of rock burst. The characteristics of rock burst in soft coal seams include a small impact influence range, large roadway deformation, and serious damage to roadway supporting components. This study examines the stress evolution and deformation response of deep and soft coal seams during mining, proposes the impact hazard factor on the basis of numerical simulation results, which takes into account the mining stress and the in-situ stress, substantiates that rock burst in a deep, soft coal seam is unlikely to occur in the absence of dynamic load. Concurrently, a static load model of the roadway surrounding rock is established, and in conjunction with the characteristics of a soft coal structure with poor integrity and low strength, the impact type of roadway is determined as the 'high static load + low dynamic load' type.
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http://dx.doi.org/10.1038/s41598-025-91619-3 | DOI Listing |
Chem Commun (Camb)
September 2025
College of Chemistry, Pingyuan Laboratory, Henan Key Laboratory of Chemical Biology and Organic Chemistry, State Key Laboratory of Coking Coal Resources Green Exploitation, Zhengzhou University, Zhengzhou 450052, P. R. China.
A visible-light-catalyzed three-component cyclization reaction of 2-vinylarylamines with CFSONa and arylaldehydes is developed to build a series of 3-(2,2,2-trifluoroethyl)-3-indoles. This protocol features mild reaction conditions using an 18 W blue LED as the light source at room temperature. The desired 3-indole products can be successfully transformed into valuable tetrahydroindole scaffolds through either reduction or cross-coupling reactions.
View Article and Find Full Text PDFOncogene
September 2025
Laboratory of Molecular Target Therapy of Cancer, Institute of Basic Medical Sciences, Hubei University of Medicine, Shiyan, Hubei, China.
Int Immunopharmacol
September 2025
The First Hospital of Anhui University of Science and Technology, Huainan 232000, China; Bengbu Medical University, Bengbu 233030, China. Electronic address:
Coal worker pneumoconiosis is an occupational pulmonary fibrosis (PF) caused by prolonged exposure to respirable coal dust (CD), with limited therapeutic options. Here, we explored the antifibrotic effects of metformin (Met) in CD-nanoparticle (CD-NP)-induced PF, focusing on its preventive and therapeutic potential. In vivo, Met was administered at different doses (low: 31.
View Article and Find Full Text PDFPLoS One
September 2025
Datong Hongtai Mine Engineering Construction Co., Ltd. of Jinneng Holding Coal Industry Group, Datong, China.
To reveal the microscopic damage evolution law of rocks under the effect of unloading disturbances with different amplitudes, electron microscope scanning, nuclear magnetic resonance (NMR), and triaxial compression tests were carried out. The evolution patterns of surface and internal pore types and mechanical properties of rock specimens after unloading perturbation were analyzed. In this paper, a classification of the ratio of dmax/dmin (dmax and dmin refer to the maximum and minimum pore size of each pore, respectively) is proposed to examine the pore and crack evolution extension development on the surface of the specimen.
View Article and Find Full Text PDFMol Divers
September 2025
State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization, Xinjiang Technical Institute of Physics and Chemistry, Chinese Academy of Sciences, Urumqi, 830011, Xinjiang, China.
Aurora kinases are a group of serine/threonine kinases essential for cell mitosis, comprising Aurora A, B, and C. However, the Aurora B is overexpressed in multiple tumors and the aurone has been proved to exhibit potent inhibitory activity against Aurora B kinase by our group. The indolinone was considered as an aurone scaffold hopping analog, and the indolinone-based Aurora B inhibitor library (3577 molecules) was constructed by FBDD strategy.
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