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http://dx.doi.org/10.1007/s13193-024-02072-z | DOI Listing |
Virchows Arch
August 2025
Department of Diagnostic Pathology, National Cancer Center Hospital, 5-1-1 Tsukiji, Chuo-Ku, Tokyo, 104-0045, Japan.
Fusion genes between the FET (EWSR1/FUS) and CREB (CREB1, ATF1, CREM) families characterize many tumor types, including mesenchymal entities. Herein, we tested the diagnostic utility of CREM (C-terminus) immunohistochemistry using 51 CREB-rearranged mesenchymal tumors and 159 tumors of 14 mimicking entities. Staining was considered positive if nuclear staining of moderate or strong intensity was observed in at least 10% of the tumor cells.
View Article and Find Full Text PDFJ Cutan Pathol
August 2025
Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA.
Background: Differentiating metastatic melanoma from histologic mimics such as malignant gastrointestinal neuroectodermal tumor (GNET), malignant melanotic nerve sheath tumor (MMNST), and epithelioid malignant peripheral nerve sheath tumor (EMPNST) poses significant diagnostic challenges due to overlapping morphology and immunophenotypes. PRAME is a novel immunohistochemical marker increasingly used to distinguish melanoma from its mimics, but remains underexplored in these rare tumor types.
Methods: PRAME immunohistochemistry was performed on four GNETs, seven MMNSTs, 10 EMPNSTs, 16 metastatic melanomas (including eight undifferentiated melanomas), and two MITF-rearranged melanocytic tumors.
Pathology
October 2025
Department of Radiation Oncology, Peter MacCallum Cancer Centre, Melbourne, Vic, Australia.
Indian J Pathol Microbiol
June 2025
Department of Surgery, Airedale General Hospital, West Yorkshire, United Kingdom.
Oxf Med Case Reports
May 2025
Pathology and Laboratory Medicine, Harbor-UCLA Medical Center, 1000 W Carson St, Torrance, California 90502, United States.
Gastrointestinal clear cell sarcoma is a rare tumor with neuroectodermal differentiation that affects the gastrointestinal tract and involves gene fusion translocations of EWSR1. These tumors predominantly occur in young adults and often display aggressive behavior, with metastases to lymph nodes and the liver. Histologically, the tumor comprises uniform round cells with round nuclei and pale eosinophilic or clear cytoplasm.
View Article and Find Full Text PDF